2.3.2.33: RCR-type E3 ubiquitin transferase

This is an abbreviated version!
For detailed information about RCR-type E3 ubiquitin transferase, go to the full flat file.

Reaction

Synonyms

E3 ubiquitin-protein ligase, MYCBP2, PHR1, RPM-1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.33 RCR-type E3 ubiquitin transferase

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1805	AA Sequence
1	Cloned(Commentary)
2	Crystallization (Commentary)
17	Disease/ Diagnostics
6	General Information
2	Localization
1	Metals/Ions
4	Natural Substrates/ Products (Substrates)
10	Organism
4	Protein Variants
3	Reaction
10	Reference
10	Source Tissue
8	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.2.33 - RCR-type E3 ubiquitin transferase

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SYSTEMATIC NAME

IUBMB Comments

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RCR-type)

RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC 2.3.2.27) that mediates ubiquitylation of acceptor proteins via an internal cysteine residue. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase. The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate.