2.3.2.33: RCR-type E3 ubiquitin transferase
This is an abbreviated version!
For detailed information about RCR-type E3 ubiquitin transferase, go to the full flat file.
Reaction
Synonyms
E3 ubiquitin-protein ligase, MYCBP2, PHR1, RPM-1
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.3.2.33 - RCR-type E3 ubiquitin transferase
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REACTION DIAGRAM
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
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[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine
[RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
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MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine
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additional information
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MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine
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