2.3.2.33: RCR-type E3 ubiquitin transferase

This is an abbreviated version!
For detailed information about RCR-type E3 ubiquitin transferase, go to the full flat file.

Reaction

Synonyms

E3 ubiquitin-protein ligase, MYCBP2, PHR1, RPM-1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.33 RCR-type E3 ubiquitin transferase

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Results	in table
1805	AA Sequence
1	Cloned(Commentary)
2	Crystallization (Commentary)
17	Disease/ Diagnostics
6	General Information
2	Localization
1	Metals/Ions
4	Natural Substrates/ Products (Substrates)
10	Organism
4	Protein Variants
3	Reaction
10	Reference
10	Source Tissue
8	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.3.2.33 - RCR-type E3 ubiquitin transferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine

[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine

Homo sapiens

O75592

-

754893

-

-

?

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [F-box protein FBXW7]-L-threonine

[E2 ubiquitin-conjugating enzyme]-L-cysteine + [F-box protein FBXW7]-3-O-ubiquitinyl-L-threonine

Homo sapiens

O75592

-

753182

-

-

?

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine

[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine

2 entries

[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine

[RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine

Homo sapiens

O75592

-

754893

-

-

?

[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [F-box protein FBXW7]-L-threonine

[RCR-type E3 ubiquitin transferase]-L-cysteine + [F-box protein FBXW7]-3-O-ubiquitinyl-L-threonine

Homo sapiens

O75592

-

753182

-

-

?

additional information

?

-

3 entries

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine

[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine

Homo sapiens

O75592

-

753182, 754893

-

-

?

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine

[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine

Homo sapiens

-

-

754893

-

-

?

additional information

?

-

Homo sapiens

O75592

MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine

754893

-

-

?

additional information

?

-

Homo sapiens

-

MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine

754893

-

-

?

additional information

?

-

Homo sapiens

O75592

F-box protein FBXW7 protein levels markedly decline during extended mitotic arrest. F-box/SPRY domain-containing protein FBXO45 binds to a conserved acidic N-terminal motif of FBXW7 specifically under a prolonged delay in mitosis, leading to ubiquitylation and subsequent proteasomal degradation of FBXW7 by the FBXO45-MYCBP2 E3 ubiquitin ligase

753182

-

-

?