2.3.2.33: RCR-type E3 ubiquitin transferase

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For detailed information about RCR-type E3 ubiquitin transferase, go to the full flat file.

Reaction

Synonyms

E3 ubiquitin-protein ligase, MYCBP2, PHR1, RPM-1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.33 RCR-type E3 ubiquitin transferase

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Results	in table
1805	AA Sequence
1	Cloned(Commentary)
2	Crystallization (Commentary)
17	Disease/ Diagnostics
6	General Information
2	Localization
1	Metals/Ions
4	Natural Substrates/ Products (Substrates)
10	Organism
4	Protein Variants
3	Reaction
10	Reference
10	Source Tissue
8	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name

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Engineering on EC 2.3.2.33 - RCR-type E3 ubiquitin transferase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

G1092E

Caenorhabditis elegans

Q17551

loss of function mutant. The residue is expected to disturb the topography of the conserved apical surface of RPM-1

754419

C4520

Homo sapiens

O75592

mutation impairs thioester-linked E3-Ub intermediate formation

754893

C4520A/C4572S

Homo sapiens

O75592

loss of activity

754893

C4572S

Homo sapiens

O75592

mutant retains activity and is able to form a discrete mono-ubiquitin adduct

754893