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2.3.1.B43: protein-lysine desuccinylase (NAD+)

This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.

Word Map on EC 2.3.1.B43

Reaction

NAD+
+
[protein]-N6-acetyl-L-lysine
=
nicotinamide
 +
[protein]-L-lysine
 +
2'-O-acetyl-ADP-ribose

Synonyms

CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.B43 protein-lysine desuccinylase (NAD+)

Source Tissue

Source Tissue on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in the cerebellar cortex, SIRT5 can be found in Purkinje cells, and is mainly distributed in the cytoplasm, but is not markedly expressed in the molecular layer or granular layer cells
Manually annotated by BRENDA team
SIRT5 and SIRT1/2 have opposite expression patterns and functions in macrophages, overview
Manually annotated by BRENDA team
SIRT5 is overexpressed in human non-small cell lung cancer cells, high expression of SIRT5 predicts poor survival
Manually annotated by BRENDA team
additional information