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2.3.1.B43: protein-lysine desuccinylase (NAD+)

This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.

Word Map on EC 2.3.1.B43

Reaction

NAD+
+
[protein]-N6-acetyl-L-lysine
=
nicotinamide
 +
[protein]-L-lysine
 +
2'-O-acetyl-ADP-ribose

Synonyms

CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.B43 protein-lysine desuccinylase (NAD+)

Expression

Expression on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
cigarette smoke extract induces the enzyme
-
decreased expression of SIRT5 is found in cultured macrophages upon primary or second LPS stimulation
enhanced expression of SIRT5 in the cerebral tissue of calorie restriction rats compared with rats that remained fed ad libitum
expression of SIRT5 increases during the progression of Alzheimer’s disease
in subcutaneous inguinal white adipose tissue, only Sirt5 expression is significantly increased after cold exposure
overexpression of AMP-activated protein kinase (AMPK) in mouse hepatocytes downregulates expression of SIRT5 mRNA by 58%. The antidiabetes drug metformin (1 mM), an established AMPK activator, reduces the mouse SIRT5 protein level by 44% in cultured hepatocytes and by 31% in liver in vivo (300 mg/kg, 7 d)
overexpression or metformin-mediated activation of AMPK inhibited SIRT5 expression
PGC-1alpha overexpression or food withdrawal increases SIRT5 mRNA and protein levels in mouse primary hepatocytes
SIRT5 expression is reported to be regulated by two major cellular regulators of metabolism, peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha), and AMP-activated protein kinase (AMPK)
SIRT5 expression is reported to be regulated by two major cellular regulators of metabolism, peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha), and AMP-activated protein kinase (AMPK). PGC-1alpha overexpression or food withdrawal increases SIRT5 mRNA and protein levels in mouse primary hepatocytes, whereas overexpression or metformin-mediated activation of AMPK inhibits SIRT5 expression
SIRT5 is significantly down-regulated in cardiomyocytes upon oxidative stress
SIRT5 is upregulated during cellular transformation and supports proliferation and tumorigenesis
sirtuin 5 (SIRT5) is upregulated in patients with type 2 diabetes and in pancreatic beta cell lines
the enzyme expression is not affected by chemical oxidant treatment
-
women with reduced ovarian reserve or advanced maternal age have decreased SIRT5 mRNA, protein and desuccinylation activity in granulosa and cumulus cells