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2.3.1.B43: protein-lysine desuccinylase (NAD+)

This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.

Word Map on EC 2.3.1.B43

Reaction

NAD+
+
[protein]-N6-acetyl-L-lysine
=
nicotinamide
 +
[protein]-L-lysine
 +
2'-O-acetyl-ADP-ribose

Synonyms

CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.B43 protein-lysine desuccinylase (NAD+)

KI Value

KI Value on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0106
benzoyl-GVL(N6-(3-acetylthiosuccinyl))KEYGV-amide
pH 7.8, 37°C
0.0172
benzoyl-GVL(N6-(3-butylsuccinyl))KEYGV-amide
pH 7.8, 37°C
0.0043
benzoyl-GVL(N6-(3-methyl-3-phenyl)succinyl)KEYGV-amide
pH 7.8, 37°C
0.1
benzoyl-GVL(N6-(3-phenyl)succinyl)KEYGV-amide
pH 7.8, 37°C
0.0381
benzoyl-GVL(N6-(N-benzyloxycarbonyl-L-aspartyl))KEYGV-amide
pH 7.8, 37°C
0.0249
benzoyl-GVL(N6-(N-phthaloyl-DL-gamma-glutamyl))KEYGV-amide
pH 7.8, 37°C
0.046
benzoyl-GVL(N6-(N2-Fmoc-beta-L-aspartyl))KEYGV-amide
pH 7.8, 37°C
0.0043
N-benzylglycyl-L-valyl-L-leucyl-N6-(3-carboxy-3-phenylbutanoyl)-L-lysyl-L-alpha-glutamyl-L-tyrosylglycyl-L-valinamide
pH 7.8, 37°C, recombinant enzyme
0.0175
nicotinamide
wild type enzyme, at pH 8.0 and 25°C