1.1.1.103: L-threonine 3-dehydrogenase
This is an abbreviated version!
For detailed information about L-threonine 3-dehydrogenase, go to the full flat file.
Reaction
Synonyms
CLOST_1621, L-ThrDH, L-threonine dehydrogenase, More, orf382, TDG, TDH, Thr dehydrogenase, ThrDH, threonine 3-dehydrogenase, threonine dehydrogenase
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.103 - L-threonine 3-dehydrogenase
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REACTION DIAGRAM
D-threonine + NAD+
(2R)-2-amino-3-oxobutanoate + NADH + H+
lowest activity
-
-
?
DL-threonine hydroxamate + NAD+
DL-2-amino-3-oxobutoxamate + NADH
-
-
-
?
L-threonine + nicotinamide guanine dinucleotide
L-2-amino-3-oxobutanoate + ?
5.1% the rate of NAD+
-
-
?
L-threonine + thionicotinamide-NAD+
L-2-amino-3-oxobutanoate + ?
5.1% the rate of NAD+
-
-
?
?
activity with mutant enzyme G114A. No activity with wild-type enzyme
-
-
?
(R)-(-)-1-amino-2-propanol + NAD+
?
activity with mutant enzyme G114A. No activity with wild-type enzyme
-
-
?
butan-2,3-dione + NADH + H+
1% of the activity compared to L-threonine
-
-
?
acetoin + NAD+
butan-2,3-dione + NADH + H+
1% of the activity compared to L-threonine
-
-
?
L-2-amino-3-oxopentanoate + NADH
-
-
-
?
DL-2-amino-3-hydroxypentanoate + NAD+
L-2-amino-3-oxopentanoate + NADH
-
-
-
?
DL-2-amino-3-oxopentanoate + NADH + H+
-
-
-
?
DL-2-amino-3-hydroxyvalerate + NAD+
DL-2-amino-3-oxopentanoate + NADH + H+
-
-
-
?
DL-2-amino-3-oxovalerate + NADH
-
-
-
?
DL-2-amino-3-hydroxyvalerate + NAD+
DL-2-amino-3-oxovalerate + NADH
-
-
-
?
3-oxonorvaline + NADH + H+
20% of the activity compared to L-threonine
-
-
?
DL-3-hydroxynorvaline + NAD+
3-oxonorvaline + NADH + H+
20% of the activity compared to L-threonine
-
-
?
? + NADH
31% the rate of L-threonine
-
-
?
DL-threo-3-hydroxynorvaline + NAD+
? + NADH
31% the rate of L-threonine
-
-
?
? + NADH
-
53% of the activity with L-threonine
-
-
?
DL-threo-3-phenylserine + NAD+
? + NADH
-
53% of the activity with L-threonine
-
-
?
DL-2-amino-3-phenyl-3-oxopropionate + NADH
-
-
-
?
DL-threo-beta-phenylserine + NAD+
DL-2-amino-3-phenyl-3-oxopropionate + NADH
-
-
-
?
DL-threo-beta-phenylserine + NAD+
DL-2-amino-3-phenyl-3-oxopropionate + NADH
-
-
-
?
L-serine + NAD+
? + NADH
-
21% of the activity with L-threonine
-
-
?
L-serine + NAD+
L-2-amino-3-oxopropionate + NADH + H+
-
-
-
-
?
L-serine + NAD+
L-2-amino-3-oxopropionate + NADH + H+
-
-
-
?
L-2-amino-3-oxobutanoate + ?
60.6% the rate of NAD+
-
-
?
L-threonine + 3-acetyl-pyridine adenine dinucleotide
L-2-amino-3-oxobutanoate + ?
60.6% the rate of NAD+
-
-
?
L-2-amino-3-oxobutanoate + ?
7.2% the rate of NAD+
-
-
?
L-threonine + 3-pyridinealdehyde adenine dinucleotide
L-2-amino-3-oxobutanoate + ?
7.2% the rate of NAD+
-
-
?
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
high activity
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
r
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
substrate binding involved residues G66, G71, G77, and V80, H94 is an active site residue
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
r
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
stereospecificity, overview
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
active site structure, overview
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
stereospecificity, overview
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
catabolism through the threonine dehydrogenase pathway does not account for the high first-pass extraction rate of dietary threonine by the portal drained viscera in pigs, overview
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
-
?
L-threonine + NAD+
(2S)-2-amino-3-oxobutanoate + NADH + H+
-
-
-
-
?
L-threonine + NAD+
L-2-amino-3-oxobutanoate + NADH + H+
the product L-2-amino-3-oxobutanoate is unstable. It spontaneously converts to 2,5-dimethylpyrazine in a pH-dependent reaction, via 3,6-dihydro-2,5-dimethylpyrazine. The reaction from aminoacetone to 2,5-dimethylpyrazine is a pH-dependent nonenzymatic reaction. Inactivation of 2-amino-3-ketobutyrate coenzyme A ligase in Bacilus subtilis improves 2,5-dimethylpyrazine production
-
-
?
L-threonine + NAD+
L-2-amino-3-oxobutanoate + NADH + H+
the product L-2-amino-3-oxobutanoate is unstable. It spontaneously converts to 2,5-dimethylpyrazine in a pH-dependent reaction, via 3,6-dihydro-2,5-dimethylpyrazine. The reaction from aminoacetone to 2,5-dimethylpyrazine is a pH-dependent nonenzymatic reaction. Inactivation of 2-amino-3-ketobutyrate coenzyme A ligase in Bacilus subtilis improves 2,5-dimethylpyrazine production
-
-
?
L-threonine + NAD+
L-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-threonine + NAD+
L-2-amino-3-oxobutanoate + NADH + H+
-
-
-
?
L-2-amino-3-oxobutyramide + NADH
-
-
-
?
L-threonine amide + NAD+
L-2-amino-3-oxobutyramide + NADH
-
-
-
?
L-threonine amide + NAD+
L-2-amino-3-oxobutyramide + NADH
-
-
-
?
L-2-amino-3-oxobutanoate methyl ester + NADH
-
-
-
?
L-threonine methyl ester + NAD+
L-2-amino-3-oxobutanoate methyl ester + NADH
-
-
-
?
L-threonine methyl ester + NAD+
L-2-amino-3-oxobutanoate methyl ester + NADH
-
-
-
?
?
-
no activity with L-theronine methyl ester, L-threonine amide, DL-threonine hydroxamate, L-homoserine, (R)-1-amino-2-propanol, L-malate, (R)-3-hydroxybutyrate, DL-threo-phenylserine, L-serine
-
-
?
additional information
?
-
-
no activity with L-theronine methyl ester, L-threonine amide, DL-threonine hydroxamate, L-homoserine, (R)-1-amino-2-propanol, L-malate, (R)-3-hydroxybutyrate, DL-threo-phenylserine, L-serine
-
-
?
additional information
?
-
no activity with L-theronine methyl ester, L-threonine amide, DL-threonine hydroxamate, L-homoserine, (R)-1-amino-2-propanol, L-malate, (R)-3-hydroxybutyrate, DL-threo-phenylserine, L-serine
-
-
?
additional information
?
-
L-threonine and DL-2-amino-3-hydroxyvalerate are the only substrates for ThrDH among other L-amino acids, alcohols, and amino alcohols, substrate specificity, overview
-
-
?
additional information
?
-
-
L-threonine and DL-2-amino-3-hydroxyvalerate are the only substrates for ThrDH among other L-amino acids, alcohols, and amino alcohols, substrate specificity, overview
-
-
?
additional information
?
-
L-threonine and DL-2-amino-3-hydroxyvalerate are the only substrates for ThrDH among other L-amino acids, alcohols, and amino alcohols, substrate specificity, overview
-
-
?
additional information
?
-
-
L-threonine and DL-2-amino-3-hydroxyvalerate are the only substrates for ThrDH among other L-amino acids, alcohols, and amino alcohols, substrate specificity, overview
-
-
?
additional information
?
-
specific for L-form of threonine, no substrate: NADP, nicotinic acid adenine dinucleotide, alpha-NAD, nicotinamide hypoxanthine dinucleotide
-
-
?
additional information
?
-
-
specific for L-form of threonine, no substrate: NADP, nicotinic acid adenine dinucleotide, alpha-NAD, nicotinamide hypoxanthine dinucleotide
-
-
?
additional information
?
-
specific for L-form of threonine, no substrate: NADP, nicotinic acid adenine dinucleotide, alpha-NAD, nicotinamide hypoxanthine dinucleotide
-
-
?
additional information
?
-
-
broad substrate specificity, determinants, overview
-
-
?
additional information
?
-
-
the enzyme is an NAD+-dependent zinc-containing medium-chain enzyme
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
ste11 gene encoding a TDH may function as a modifier gene of ebosin during its biosynthesis
-
-
?