EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.4.23.3 | gastricsin |
breast |
the enzyme is produced by mammary carcinomas and cysts, but not by the normal resting mammary gland |
36861 |
3.5.2.9 | 5-oxoprolinase (ATP-hydrolysing) |
breast |
normal and cancer tissues |
209389, 209391 |
3.5.4.3 | guanine deaminase |
breast |
cancerous and non-cancerous |
209600 |
7.2.2.9 | P-type Cu2+ transporter |
breast |
expression is greater in lactating tissue than in nonlactating tissue, detected in luminal epithelial cells of the alveoli and ducts but not in myoepithelial cells |
246918 |
3.6.1.29 | bis(5'-adenosyl)-triphosphatase |
breast |
- |
289061, 668869 |
2.4.1.17 | glucuronosyltransferase |
breast |
- |
488786, 488790, 735649, 759116 |
2.4.2.4 | thymidine phosphorylase |
breast |
tumor specimen |
638461, 638468 |
2.4.2.4 | thymidine phosphorylase |
breast |
ductal carcinoma in situ and invasive elements |
638469 |
2.7.11.18 | myosin-light-chain kinase |
breast |
- |
640647 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast |
- |
640931, 640952 |
2.7.1.137 | phosphatidylinositol 3-kinase |
breast |
- |
640952 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast |
low amount of isozyme PI3K-C2alpha in myoepithelial cells and lactiferous ducts, no isozyme PI3K-C2beta and isozyme p85 |
645046 |
2.8.2.2 | alcohol sulfotransferase |
breast |
cancer tissue |
645741 |
3.4.21.35 | tissue kallikrein |
breast |
lower content |
647332 |
3.4.21.77 | semenogelase |
breast |
female |
647332 |
3.4.21.B10 | neurosin |
breast |
high expression level |
647332 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
high expression level |
647332 |
3.4.21.B12 | prostase |
breast |
- |
647334 |
3.4.21.B43 | kallikrein 12 |
breast |
gene expression of the enzyme is down-regulated in breast cancer |
647367 |
3.4.21.B43 | kallikrein 12 |
breast |
low content |
647367 |
3.4.21.119 | kallikrein 13 |
breast |
- |
647372, 647373 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
breast |
cancer stroma cells |
650762 |
1.2.1.36 | retinal dehydrogenase |
breast |
- |
655948 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast |
- |
656371, 686263, 713021, 740542 |
3.1.6.2 | steryl-sulfatase |
breast |
fibroblasts from normal and malignant breast tissue, study of the regulation of STS mRNA expression |
656640 |
1.3.1.21 | 7-dehydrocholesterol reductase |
breast |
exocrine, high desmosterol synthesis |
656819 |
2.7.1.40 | pyruvate kinase |
breast |
activity in tumor tissue is higher than in normal tissue |
660823 |
6.3.4.3 | formate-tetrahydrofolate ligase |
breast |
higher expression level |
660866 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast |
high expression level of ErbB1 receptor |
660873 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast |
Frk, Brk, Src, Fyn, Yes |
660885 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast |
- |
661457 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast |
epithelium, Syk occurs in MDA-MB-468 cells, but not in BT-549 cells |
661457 |
5.3.99.3 | prostaglandin-E synthase |
breast |
in normal breast the enzyme is seen in myoepithelial cells and in stromal fibroblasts and vascular smooth muscle, in breast disease, the enzyme is observed in epithelial cells adjacent to cancer, in scattered foci of fibrocystic disease, in ductal carcinoma in situ and in invasive cancers, in addition to myoepithelial cells |
662700 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
breast |
- |
662996 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
breast |
- |
664248 |
3.2.1.35 | hyaluronoglucosaminidase |
breast |
HPH-20 |
664596 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
breast |
- |
665600 |
2.7.11.24 | mitogen-activated protein kinase |
breast |
- |
665638 |
3.5.4.4 | adenosine deaminase |
breast |
- |
668272, 718704 |
3.4.17.21 | Glutamate carboxypeptidase II |
breast |
quantitative expression analysis |
670740 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
high expression |
670978 |
3.4.21.B41 | kallikrein 10 |
breast |
expression in normal cells, but no expression in breast cancer cells |
670979 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast |
- |
671357, 672857, 675686, 695621 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
breast |
- |
672280 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast |
PI3KC2gamma |
672858 |
2.7.1.32 | choline kinase |
breast |
- |
673201 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
breast |
AGT expression is increased in breast cancer compared to normal breast |
673219 |
1.14.13.8 | flavin-containing monooxygenase |
breast |
- |
673313 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
breast |
- |
674069 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast |
enzyme expression analysis in different samples of women with and without breast cancer, no correlation with breast cancer development |
675679 |
2.8.2.2 | alcohol sulfotransferase |
breast |
- |
675680 |
2.7.11.19 | phosphorylase kinase |
breast |
- |
676038 |
2.3.1.5 | arylamine N-acetyltransferase |
breast |
healthy and neoplastic tissue |
676155 |
2.7.11.10 | IkappaB kinase |
breast |
- |
676886 |
3.4.22.15 | cathepsin L |
breast |
- |
678521 |
3.4.21.35 | tissue kallikrein |
breast |
KLK4 |
678522 |
3.4.21.B41 | kallikrein 10 |
breast |
- |
678524 |
2.7.1.3 | ketohexokinase |
breast |
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues |
678985 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
breast |
mRNA expression levels in normal breast tissue are not significantly different between premenopausal and postmenopausal women for both UCH-L1 and UCH-L3 |
679040 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
- |
680680 |
3.1.6.2 | steryl-sulfatase |
breast |
moderate level of enzyme immunoreactivity |
681644 |
3.4.21.34 | plasma kallikrein |
breast |
synthesis of prekallikrein |
683208 |
3.4.19.9 | folate gamma-glutamyl hydrolase |
breast |
- |
683368 |
3.4.21.109 | matriptase |
breast |
- |
683492 |
3.4.24.56 | insulysin |
breast |
- |
683571 |
3.4.21.B41 | kallikrein 10 |
breast |
KLK10 is not methylated in normal breast tissues and fibroadenomas while it is in 5 of 10 breast tumors and in 1 of 10 matching normal tissues |
690443 |
3.1.3.11 | fructose-bisphosphatase |
breast |
- |
690771 |
2.8.2.4 | estrone sulfotransferase |
breast |
- |
671361, 674994, 691194, 691624 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
breast |
- |
694494 |
2.2.1.1 | transketolase |
breast |
only 29% of non-neoplastic breast tissues are TKTL1 immunopositive, including 9% with high expression levels |
694502 |
2.7.11.13 | protein kinase C |
breast |
- |
695064 |
2.4.1.17 | glucuronosyltransferase |
breast |
identification of isozyme UGT1A10 in non-malignant and malignant human breast tissues, UGT1A10 and UGT2B7 mRNAs are differentially expressed among healthy and malignant specimens, in African American women, UGT1A10 expression is significantly decreased in breast carcinomas in comparison to healthy, while among Caucasian women, overview |
695149 |
2.4.1.17 | glucuronosyltransferase |
breast |
UGT1A10 and UGT2B7 mRNAs are differentially expressed among healthy and malignant specimens, in African American women, UGT2B7 is significantly decreased in breast carcinomas in comparison to healthy, overview |
695149 |
4.1.1.17 | ornithine decarboxylase |
breast |
epithelial cells |
695299 |
3.4.14.5 | dipeptidyl-peptidase IV |
breast |
- |
695514 |
3.4.24.56 | insulysin |
breast |
female breast |
696530 |
1.1.1.188 | prostaglandin-F synthase |
breast |
normal breast expresses very high levels of AKR1C3 relative to other tissues |
697271 |
3.4.22.38 | cathepsin K |
breast |
high expression level |
697375 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
breast |
- |
698156 |
2.7.1.91 | sphingosine kinase |
breast |
- |
671356, 702084 |
2.7.11.21 | polo kinase |
breast |
- |
703598 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
breast |
- |
704836 |
2.7.8.2 | diacylglycerol cholinephosphotransferase |
breast |
- |
705452 |
3.4.13.9 | Xaa-Pro dipeptidase |
breast |
- |
707010 |
3.1.6.12 | N-acetylgalactosamine-4-sulfatase |
breast |
- |
707573 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast |
- |
647332, 707996 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7 expression and and clinicopathological factors. mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, overview. mRNA levels of KLK5 and KLK7 are both downregulated in breast cancers relative to normal and benign tissues, and downregulated in metastases compared to primary cancers |
707996 |
3.4.24.B3 | matrix metalloproteinase-11 |
breast |
- |
708156 |
2.7.11.1 | non-specific serine/threonine protein kinase |
breast |
- |
708371 |
3.4.24.35 | gelatinase B |
breast |
- |
696965, 710650 |
3.4.24.B7 | matrix metalloproteinase-26 |
breast |
- |
710794 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
breast |
- |
711688 |
3.1.6.2 | steryl-sulfatase |
breast |
- |
714906 |
3.4.21.109 | matriptase |
breast |
co-expression of matriptase and its substrate serine protease prostasin |
717902 |
3.4.21.B6 | prostasin |
breast |
co-expression of matriptase and its substrate serine protease prostasin |
717902 |
3.4.21.77 | semenogelase |
breast |
surgical specimens from female patients with breast cancer |
718164 |
2.7.1.147 | ADP-specific glucose/glucosamine kinase |
breast |
- |
723169 |
1.14.14.79 | docosahexaenoic acid omega-hydroxylase |
breast |
- |
728344 |
3.4.21.B10 | neurosin |
breast |
- |
731397 |
3.4.22.B29 | calpain 9 |
breast |
expression analysis |
731549 |