Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation loop structure of Src and of Csk, autophosphorylation sites | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | as MgATP- | Rous sarcoma virus | |
Mg2+ | as MgATP2- | Gallus gallus | |
Mg2+ | as MgATP2-, binds to Asp404, physiological cation, can be substituted by Mn2+ | Homo sapiens | |
Mn2+ | - |
Gallus gallus | |
Mn2+ | - |
Rous sarcoma virus | |
Mn2+ | binds to Asp404, can substitute for Mg2+ | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Gallus gallus | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | Rous sarcoma virus | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
additional information | Gallus gallus | Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview | ? | - |
? | |
additional information | Homo sapiens | Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview | ? | - |
? | |
additional information | Rous sarcoma virus | Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Rous sarcoma virus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview | Gallus gallus |
phosphoprotein | enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview | Rous sarcoma virus |
phosphoprotein | enzyme autophosphorylates at Tyr416 the activation loop for activation, inhibition of Src by phosphorylation at the regulatory tyrosine Tyr527 residue by the C-terminal Src kinase Csk, phosphorylation sites, detailed overview | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | structure-function relation ship, active site structure, catalytic mechanism involving the catalytic base Asp386 and enzyme regulation, overview | Homo sapiens | |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview | Gallus gallus | |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview | Rous sarcoma virus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | Frk, Src, Fyn, Yes | Homo sapiens | - |
brain | Frk, Src, Fyn, Yes | Homo sapiens | - |
breast | Frk, Brk, Src, Fyn, Yes | Homo sapiens | - |
colon | Brk, Frk, Src, Fyn, Yes | Homo sapiens | - |
hematopoietic cell | Blk, Fgr, Hck, Lck, and Lyn, primarily, Src, Fyn, Yes | Homo sapiens | - |
keratinocyte | Srm, Src, Fyn, Yes | Homo sapiens | - |
lymphoid cell | Frk, Src, Fyn, Yes | Homo sapiens | - |
additional information | Src is dormant during most of the cell cycle, Src, Fyn, Yes are expressed in all cell types | Homo sapiens | - |
prostate | Brk, Src, Fyn, Yes | Homo sapiens | - |
small intestine | Brk, Src, Fyn, Yes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Gallus gallus | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | - |
Rous sarcoma virus | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | substrate docking-site and binding structure of Src involving R279, R281, and R283 | Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
additional information | Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview | Gallus gallus | ? | - |
? | |
additional information | Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview | Homo sapiens | ? | - |
? | |
additional information | Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview | Rous sarcoma virus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview | Gallus gallus |
More | enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview | Rous sarcoma virus |
More | enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview, active and inactive conformation of Src, structure of Csk | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Blk | - |
Homo sapiens |
Brk | - |
Homo sapiens |
C-terminal Src kinase | - |
Homo sapiens |
Csk | - |
Homo sapiens |
Fgr | - |
Homo sapiens |
FRK | - |
Homo sapiens |
Fyn | - |
Homo sapiens |
HCK | - |
Homo sapiens |
Lck | - |
Homo sapiens |
Lyn | - |
Homo sapiens |
More | the Src kinase family contains 11 members, i.e. protein tyrosine kinases Blk, Brk, Fgr, Frk, Fyn, Hck, Lck, Lyn, Src, Srm, and Yes | Homo sapiens |
PTK | - |
Homo sapiens |
Src | - |
Gallus gallus |
Src | - |
Homo sapiens |
Src protein-tyrosine kinase | - |
Gallus gallus |
Src protein-tyrosine kinase | - |
Homo sapiens |
Src protein-tyrosine kinase | - |
Rous sarcoma virus |
Srm | - |
Homo sapiens |
v-Src | - |
Rous sarcoma virus |
Yes | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | as MgATP-, binding site structure | Homo sapiens | |
ATP | as MgATP2-, binding site structure | Gallus gallus | |
ATP | as MgATP2-, binding site structure | Rous sarcoma virus |