Application | Comment | Organism |
---|---|---|
medicine | possible involvement of UCH-L1 and UCH-L3 in the pathogenesis and progression of breast cancer. High UCH-L1 mRNA level is significantly associated with negative estrogen receptor status and negative progesterone receptor status. Patients with both UCH-L1 and UCH-L3 mRNA high tumors show a significantly poorer prognosis than those in the UCH-L1 or UCH-L3 mRNA low group | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | mRNA expression levels in normal breast tissue are not significantly different between premenopausal and postmenopausal women for both UCH-L1 and UCH-L3 | Homo sapiens | - |
breast cancer cell | UCH-L3 mRNA level is significantly upregulated and UHCL1 mRNA level also show a non-significant increase in breast cancer tissue compared to adjacent normal breast tissue. Both UCH-L1 and UCH-L3 mRNA levels are significantly higher in high histological grade tumors than in low histological grade tumors. UCH-L1 mRNA level in tumors is approximately 10 times higher than that of UCH-L3 | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxy-terminal hydrolase-L1 | - |
Homo sapiens |
ubiquitin carboxy-terminal hydrolase-L3 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |
UCH-L3 | - |
Homo sapiens |