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Literature summary for 3.4.21.B39 extracted from

  • Debela, M.; Magdolen, V.; Schechter, N.; Valachova, M.; Lottspeich, F.; Craik, C.S.; Choe, Y.; Bode, W.; Goettig, P.
    Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences (2006), J. Biol. Chem., 281, 25678-25688.
    View publication on PubMed
Search for more literature for 3.4.21.B39

Cloned(Commentary)

Cloned (Comment) Organism
expressed in insect cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y337
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
skin
-
 Homo sapiens
-
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information displays a trypsin-like specificity with strong preference for Arg at position P1. The S1 pocket of hK5 is very specific for P1-Arg side chains. Thr, Asn, Gln, and Ile are tolerated at position P1, whereas the residual amino acids, in particular with large aromatic side chains and Lys, are hardly accepted. Ser is slightly preferred over Asn, Thr, and Ala at position P2, whereas among all other residues only Arg and Tyr are rejected. Most amino acids, in particular Met, Phe, and Tyr but not Asp, are accepted in position P3. An unusual preference for Gly followed by Tyr, Val, and Pro is observed at position P4 Homo sapiens ?
-
 ?
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O best substrate Homo sapiens ?
-
 ?
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O best substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
hK5
-
 Homo sapiens
human stratum corneum trypsin-like enzyme
-
 Homo sapiens