Literature summary for 3.4.21.B39 extracted from

Li, X.; Liu, J.; Wang, Y.; Zhang, L.; Ning, L.; Feng, Y.
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies (2009), Cancer Sci., 100, 601-607.

Search for more literature for 3.4.21.B39

Application

Application	Comment	Organism
diagnostics	KLK5 is a potential biomarker for breast cancer	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene KLK5, located at the chromosomal locus 19q13.3-q13.4, quantitative real-time PCR expression analysis, 10 transcription factors as potential regulators were found on the control regions of both KLK5 and KLK7	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7 expression and and clinicopathological factors. mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, overview. mRNA levels of KLK5 and KLK7 are both downregulated in breast cancers relative to normal and benign tissues, and downregulated in metastases compared to primary cancers	Homo sapiens	-
breast cancer cell	expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7 expression and and clinicopathological factors. mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, overview. mRNA levels of KLK5 and KLK7 are both downregulated in breast cancers relative to normal and benign tissues, and downregulated in metastases compared to primary cancers	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein 5	-	Homo sapiens
KLK5	-	Homo sapiens
More	the enzyme belongs to the human kallikrein, KLK, gene family	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	10 transcription factors as potential regulators are found on the control regions of both KLK5 and KLK7	additional information

General Information

General Information	Comment	Organism
malfunction	KLK5 and KLK7 are underexpressed in parallel, potentially with the same regulation pathways, in breast malignancies, which might contribute to the carcinogenesis and development of breast cancer	Homo sapiens

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Release 2023.1 (January 2023)