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EC 1.14.13.121 Details
show Brenda entryEC number
1.14.13.121
Accepted name
premnaspirodiene oxygenase
Reaction
(–)-vetispiradiene + 2 NADPH + 2 H+ + 2 O2 = solavetivone + 2 NADP+ + 3 H2O (overall reaction);;(1a) (–)-vetispiradiene + NADPH + H+ + O2 = solavetivol + NADP+ + H2O;;(1b) solavetivol + NADPH + H+ + O2 = solavetivone + NADP+ + 2 H2O
Other name(s)
HPO,
Hyoscymus muticus premnaspirodiene oxygenase
Systematic name
(–)-vetispiradiene,NADPH:oxygen 2α-oxidoreductase
Comment
A heme-thiolate protein (P-450). The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the α-hydroxy compound, nootkatol, and this is converted into nootkatone. 5-Epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2β-hydroxy derivative which is not further oxidized.
History
created 2011, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000 1.14.13.45 created 1992, deleted 2003
