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EC 1.14.13.111 Details
show Brenda entryEC number
1.14.13.111
Accepted name
methanesulfonate monooxygenase (NADH)
Reaction
methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O
Other name(s)
mesylate monooxygenase,
mesylate,reduced-FMN:oxygen oxidoreductase,
MsmABC,
methanesulfonic acid monooxygenase,
MSA monooxygenase,
MSAMO
Systematic name
methanesulfonate,NADH:oxygen oxidoreductase
Comment
A flavoprotein. Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Compared with EC 1.14.14.5, alkanesulfonate monooxygenase, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methanesulfonate to butanesulfonate) and excludes all larger molecules, such as arylsulfonates [1]. The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising a hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC). The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] cluster. cf. EC 1.14.14.34, methanesulfonate monooxygenase (FMNH2).
History
created 2009 as EC 1.14.14.6, transferred 2010 to EC 1.14.13.111, modified 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000 1.14.13.45 created 1992, deleted 2003
