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EC 2.4.2.36 Details

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EC number

2.4.2.36

Accepted name

NAD⁺—diphthamide ADP-ribosyltransferase

Reaction

NAD⁺ + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]

Other name(s)

ADP-ribosyltransferase, mono(ADPribosyl)transferase, NAD—diphthamide ADP-ribosyltransferase, NAD⁺:peptide-diphthamide N-(ADP-D-ribosyl)transferase

Systematic name

NAD⁺:diphthamide-[translation elongation factor 2] N-(ADP-D-ribosyl)transferase

CAS registry number

52933-21-8

Comment

Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC 2.4.2.31 NAD(P)⁺—protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His⁷¹⁵ in mammals, His⁶⁹⁹ in yeast and His⁶⁰⁰ in Pyrococcus horikoshii.

History

created 1990, modified 2013

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.17.1 With NAD⁺ or NADP⁺ as acceptor

1.17.2 With a cytochrome as acceptor

1.17.3 With oxygen as acceptor

1.17.4 With a disulfide as acceptor

1.17.5 With a quinone or similar compound as acceptor

1.17.7 With an iron-sulfur protein as acceptor

1.17.8 With a flavin as acceptor

1.17.9 With a copper protein as acceptor

1.17.98 With other, known, physiological acceptors

1.17.99 With unknown physiological acceptors

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.20.1 With NAD⁺ or NADP⁺ as acceptor

1.20.2 With a cytochrome as acceptor

1.20.4 With disulfide as acceptor

1.20.9 With a copper protein as acceptor

1.20.98 With other, known, physiological acceptors

1.20.99 With unknown physiological acceptors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.2 Pentosyltransferases

2.4.2.1 purine-nucleoside phosphorylase

2.4.2.2 pyrimidine-nucleoside phosphorylase

2.4.2.3 uridine phosphorylase

2.4.2.4 thymidine phosphorylase

2.4.2.5 nucleoside ribosyltransferase

2.4.2.6 nucleoside deoxyribosyltransferase

2.4.2.7 adenine phosphoribosyltransferase

2.4.2.8 hypoxanthine phosphoribosyltransferase

2.4.2.9 uracil phosphoribosyltransferase

2.4.2.10 orotate phosphoribosyltransferase

2.4.2.11 nicotinate phosphoribosyltransferase

2.4.2.12 nicotinamide phosphoribosyltransferase

2.4.2.13 created 1961, deleted 1965

2.4.2.14 amidophosphoribosyltransferase

2.4.2.15 guanosine phosphorylase

2.4.2.16 urate-ribonucleoside phosphorylase

2.4.2.17 ATP phosphoribosyltransferase

2.4.2.18 anthranilate phosphoribosyltransferase

2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating)

2.4.2.20 dioxotetrahydropyrimidine phosphoribosyltransferase

2.4.2.21 nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase

2.4.2.22 xanthine phosphoribosyltransferase

2.4.2.23 deoxyuridine phosphorylase

2.4.2.24 1,4-β-D-xylan synthase

2.4.2.25 flavone apiosyltransferase

2.4.2.26 protein xylosyltransferase

2.4.2.27 dTDP-dihydrostreptose—streptidine-6-phosphate dihydrostreptosyltransferase

2.4.2.28 S-methyl-5′-thioadenosine phosphorylase

2.4.2.29 tRNA-guanosine³⁴ preQ₁ transglycosylase

2.4.2.30 NAD⁺ ADP-ribosyltransferase

2.4.2.31 NAD⁺—protein-arginine ADP-ribosyltransferase

2.4.2.32 dolichyl-phosphate D-xylosyltransferase

2.4.2.33 dolichyl-xylosyl-phosphate—protein xylosyltransferase

2.4.2.34 indolylacetylinositol arabinosyltransferase

2.4.2.35 flavonol-3-O-glycoside xylosyltransferase

2.4.2.36 NAD⁺—diphthamide ADP-ribosyltransferase

2.4.2.37 NAD⁺—dinitrogen-reductase ADP-D-ribosyltransferase

2.4.2.38 glycoprotein 2-β-D-xylosyltransferase

2.4.2.39 xyloglucan 6-xylosyltransferase

2.4.2.40 zeatin O-β-D-xylosyltransferase

2.4.2.41 xylogalacturonan β-1,3-xylosyltransferase

2.4.2.42 UDP-D-xylose:β-D-glucoside α-1,3-D-xylosyltransferase

2.4.2.43 lipid IV_A 4-amino-4-deoxy-L-arabinosyltransferase

2.4.2.44 S-methyl-5′-thioinosine phosphorylase

2.4.2.45 decaprenyl-phosphate phosphoribosyltransferase

2.4.2.46 galactan 5-O-arabinofuranosyltransferase

2.4.2.47 arabinofuranan 3-O-arabinosyltransferase

2.4.2.48 tRNA-guanine¹⁵ transglycosylase

2.4.2.49 neamine phosphoribosyltransferase

2.4.2.50 cyanidin 3-O-galactoside 2′′-O-xylosyltransferase

2.4.2.51 anthocyanidin 3-O-glucoside 2′′′-O-xylosyltransferase

2.4.2.52 triphosphoribosyl-dephospho-CoA synthase

2.4.2.53 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

2.4.2.54 β-ribofuranosylphenol 5′-phosphate synthase

2.4.2.55 nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase

2.4.2.56 kaempferol 3-O-xylosyltransferase

2.4.2.57 AMP phosphorylase

2.4.2.58 hydroxyproline O-arabinosyltransferase

2.4.2.59 sulfide-dependent adenosine diphosphate thiazole synthase

2.4.2.60 cysteine-dependent adenosine diphosphate thiazole synthase

2.4.2.61 α-dystroglycan β1,4-xylosyltransferase

2.4.2.62 xylosyl α-1,3-xylosyltransferase

2.4.2.63 EGF-domain serine xylosyltransferase

2.4.2.64 tRNA-guanosine³⁴ queuine transglycosylase

2.4.3 Sialyltransferases

2.4.99 Transferring other glycosyl groups

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

7.1 Catalysing the translocation of hydrons

7.2 Catalysing the translocation of inorganic cations

7.3 Catalysing the translocation of inorganic anions and their chelates

7.4 Catalysing the translocation of amino acids and peptides

7.5 Catalysing the translocation of carbohydrates and their derivatives

7.6 Catalysing the translocation of other compounds

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Release 2023.1 (January 2023)