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EC 2.4.2.30 Details
EC number
2.4.2.30
Accepted name
NAD+ ADP-ribosyltransferase
Reaction
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
Other name(s)
poly(ADP-ribose) synthase,
ADP-ribosyltransferase (polymerizing),
NAD ADP-ribosyltransferase,
PARP,
PARP-1,
NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase (incorrect),
NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Systematic name
NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
CAS registry number
58319-92-9
Comment
The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2′-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20–30 units.
History
created 1984, modified 1990
EC Tree
2.4.2.13 created 1961, deleted 1965