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EC 2.4.2.31 Details
EC number
2.4.2.31
Accepted name
NAD+—protein-arginine ADP-ribosyltransferase
Reaction
NAD+ + protein L-arginine = nicotinamide + Nω-(ADP-D-ribosyl)-protein-L-arginine
Other name(s)
ADP-ribosyltransferase,
mono(ADP-ribosyl)transferase,
NAD+:L-arginine ADP-D-ribosyltransferase,
NAD(P)+-arginine ADP-ribosyltransferase,
NAD(P)+:L-arginine ADP-D-ribosyltransferase,
mono-ADP-ribosyltransferase,
ART,
ART1,
ART2,
ART3,
ART4,
ART5,
ART6,
ART7,
NAD(P)+—protein-arginine ADP-ribosyltransferase,
NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase
Systematic name
NAD+:protein-L-arginine ADP-D-ribosyltransferase
CAS registry number
81457-93-4
Comment
Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nω-[(2′-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymic activities. (cf. EC 2.4.2.36 NAD+—diphthamide ADP-ribosyltransferase).
History
created 1984, modified 1990, modified 2006
EC Tree
2.4.2.13 created 1961, deleted 1965