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EC 2.4.2.19 Details
EC number
2.4.2.19
Accepted name
nicotinate-nucleotide diphosphorylase (carboxylating)
Reaction
β-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-α-D-ribose 1-diphosphate
Other name(s)
quinolinate phosphoribosyltransferase (decarboxylating),
quinolinic acid phosphoribosyltransferase,
QAPRTase,
NAD+ pyrophosphorylase,
nicotinate mononucleotide pyrophosphorylase (carboxylating),
quinolinic phosphoribosyltransferase
Systematic name
β-nicotinate-D-ribonucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
CAS registry number
37277-74-0
Comment
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3].
History
created 1972
EC Tree
2.4.2.13 created 1961, deleted 1965