2.6.1.B16: amine transaminase
This is an abbreviated version!
For detailed information about amine transaminase, go to the full flat file.
Reaction
Synonyms
(S)-amine-transaminase, (S)-ATA, (S)-selective amine transaminase, (S)-selective Chromobacterium violaceum omega-transaminase, (S)-selective omega-transaminase, amine transaminase, amine-transaminases, ATA, ATA_SLM16, Ban-TA, Cv-ATA, Cv-omegaTA, HELO 1904, HEWT, omega-amino acid:pyruvate transaminase, omega-TA, omega-transaminase, Rsp-ATA, SpuC
ECTree
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Cofactor
Cofactor on EC 2.6.1.B16 - amine transaminase
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pyridoxal 5'-phosphate
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dependent on. Many PLP-dependent enzymes, including transaminases, require the formation of a so-called internal aldimine (E-PLP), before the main reaction. In this process, the PLP coenzyme becomes covalently bound to an active-site lysine residue as a protonated Schiff base, which constitutes the active form of the enzyme. The transamination reaction consists of two half-transamination equilibria. An amino donor is converted to the corresponding ketone or aldehyde, resulting in the conversion of E-PLP to pyridoxamine-5'-phosphate (PMP). The E-PLP is then regenerated by the reaction of another ketone or aldehyde, which is then converted into an amine
pyridoxal 5'-phosphate
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PLP has a crucial role in dimerstabilization