2.3.1.253: phloroglucinol synthase

This is an abbreviated version!
For detailed information about phloroglucinol synthase, go to the full flat file.

Reaction

3 malonyl-CoA =

Synonyms

PhlD, phloroglucinol synthase, type III polyketide synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.253 phloroglucinol synthase

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Results	in table
7	AA Sequence
4	Application
7	Cloned(Commentary)
7	kcat/KM [mM/s]
8	KM Value [mM]
2	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
44	Organism
1	pH Optimum
41	Protein Variants
3	Purification (Commentary)
1	Reaction
22	Reference
1	Specific Activity [micromol/min/mg]
40	Substrates and Products (Substrate)
4	Subunits
36	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
8	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.253 - phloroglucinol synthase

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SYSTEMATIC NAME

IUBMB Comments

malonyl-CoA:malonyl-CoA malonyltransferase (decarboxylating, phloroglucinol-forming)

The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase. The mechanism involves the cyclization of an activated 3,5-dioxoheptanedioate intermediate. The enzyme exhibits broad substrate specificity, and can accept C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming 6-(polyoxoalkyl)-alpha-pyrones by sequential condensation with malonyl-CoA.