2.3.1.253: phloroglucinol synthase
This is an abbreviated version!
For detailed information about phloroglucinol synthase, go to the full flat file.
Reaction
3 malonyl-CoA
=
Synonyms
PhlD, phloroglucinol synthase, type III polyketide synthase
ECTree
2.3.1.253 phloroglucinol synthaseAdvanced search results
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Substrates Products on EC 2.3.1.253 - phloroglucinol synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
decanoyl-CoA
4-hydroxy-6-octyl-2H-pyran-2-one + 4-hydroxy-6-(2-oxoundecyl)-2H-pyran-2-one + 4-hydroxyl-6-(2',4',6'-trioxopentadecyl)-2-pyrone + CO2 + CoA
hexanoyl-CoA
4-hydroxy-6-pentyl-2H-pyran-2-one + 4-hydroxy-6-(2-oxoheptyl)-2H-pyran-2-one + CO2 + CoA
8% activity compared to malonyl-CoA
-
-
?
lauroyl-CoA
6-decyl-4-hydroxy-2H-pyran-2-one + 4-hydroxy-6-(2-oxotridecyl)-2H-pyran-2-one + CO2 + CoA
7.6% activity compared to malonyl-CoA
-
-
?
octanoyl-CoA
6-heptyl-4-hydroxy-2H-pyran-2-one + 4-hydroxy-6-(2-oxononyl)-2H-pyran-2-one + 4-hydroxyl-6-(2',4',6'-trioxotridecyl)-2-pyrone + 4-hydroxyl-6-(2',4',6',8'-tetraoxopentadecyl)-2-pyrone + CO2 + CoA
7% activity compared to malonyl-CoA
-
-
?
phenylacetyl-CoA
6-(cyclohepta-1,3,6-trien-1-yl)-4-hydroxy-2H-pyran-2-one + 6-[2-(cyclohepta-1,3,6-trien-1-yl)-2-oxoethyl]-4-hydroxy-2H-pyran-2-one + CO2 + CoA
3.3% activity compared to malonyl-CoA
-
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
-
-
-
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
-
-
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
-
-
phloroglucinol is 1,3,5-trihydroxylbenzene
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
preferred substrate
-
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
-
-
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
-
-
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
-
-
phloroglucinol is 1,3,5-trihydroxylbenzene
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
preferred substrate
-
-
?
3 malonyl-CoA
phloroglucinol + 3 CO2 + 3 CoA
-
-
-
?
acetoacetyl-CoA
phloroglucinol + 4-hydroxy-6-methyl-2H-pyran-2-one + CO2 + CoA
1.6% activity compared to malonyl-CoA
-
-
?
acetoacetyl-CoA
phloroglucinol + 4-hydroxy-6-methyl-2H-pyran-2-one + CO2 + CoA
1.6% activity compared to malonyl-CoA
-
-
?
butyryl-CoA
phloroglucinol + 4-hydroxy-6-propyl-2H-pyran-2-one + CO2 + CoA
0.2% activity compared to malonyl-CoA
-
-
?
butyryl-CoA
phloroglucinol + 4-hydroxy-6-propyl-2H-pyran-2-one + CO2 + CoA
0.2% activity compared to malonyl-CoA
-
-
?
decanoyl-CoA
4-hydroxy-6-octyl-2H-pyran-2-one + 4-hydroxy-6-(2-oxoundecyl)-2H-pyran-2-one + 4-hydroxyl-6-(2',4',6'-trioxopentadecyl)-2-pyrone + CO2 + CoA
18% activity compared to malonyl-CoA
-
-
?
decanoyl-CoA
4-hydroxy-6-octyl-2H-pyran-2-one + 4-hydroxy-6-(2-oxoundecyl)-2H-pyran-2-one + 4-hydroxyl-6-(2',4',6'-trioxopentadecyl)-2-pyrone + CO2 + CoA
18% activity compared to malonyl-CoA
-
-
?
additional information
?
-
the enzyme shows barely detectable activity toward acetyl-CoA, isobutyryl-CoA, benzoyl-CoA, and crotonyl-CoA. No activity with myristoyl-CoA and palmitoyl-CoA
-
-
?
additional information
?
-
acetate is successfully transformed into phloroglucinol by the combined activity of recombinant acetyl-CoA carboxylase (ACC) from Acinetobacter calcoaceticus strain CGMCC 1.6186 and recombinant phloroglucinol synthase (PhlD) from Pseudomonas fluorescens strain Pf-5 in an in vitro system, synthetic pathway of phloroglucinol and in vitro synthesis of phloroglucinol from acetate, method optimization, overview
-
-
-
additional information
?
-
acetate is successfully transformed into phloroglucinol by the combined activity of recombinant acetyl-CoA carboxylase (ACC) from Acinetobacter calcoaceticus strain CGMCC 1.6186 and recombinant phloroglucinol synthase (PhlD) from Pseudomonas fluorescens strain Pf-5 in an in vitro system, synthetic pathway of phloroglucinol and in vitro synthesis of phloroglucinol from acetate, method optimization, overview
-
-
-
additional information
?
-
acetate is successfully transformed into phloroglucinol by the combined activity of recombinant acetyl-CoA carboxylase (ACC) from Acinetobacter calcoaceticus strain CGMCC 1.6186 and recombinant phloroglucinol synthase (PhlD) from Pseudomonas fluorescens strain Pf-5 in an in vitro system, synthetic pathway of phloroglucinol and in vitro synthesis of phloroglucinol from acetate, method optimization, overview
-
-
-
additional information
?
-
the enzyme shows barely detectable activity toward acetyl-CoA, isobutyryl-CoA, benzoyl-CoA, and crotonyl-CoA. No activity with myristoyl-CoA and palmitoyl-CoA
-
-
?
additional information
?
-
acetate is successfully transformed into phloroglucinol by the combined activity of recombinant acetyl-CoA carboxylase (ACC) from Acinetobacter calcoaceticus strain CGMCC 1.6186 and recombinant phloroglucinol synthase (PhlD) from Pseudomonas fluorescens strain Pf-5 in an in vitro system, synthetic pathway of phloroglucinol and in vitro synthesis of phloroglucinol from acetate, method optimization, overview
-
-
-
