1.17.99.9: heme a synthase

This is an abbreviated version!
For detailed information about heme a synthase, go to the full flat file.

Reaction

Synonyms

ape1694, cCtaA, COX15, COX15p, ctaA, CtaA protein, HAS, TcCox15

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.99 With unknown physiological acceptors

                1.17.99.9 heme a synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
6005	AA Sequence
15	Cloned(Commentary)
9	Cofactor
2	Expression
18	General Information
3	General Stability
20	Localization
3	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
75	Organism
2	Oxidation Stability
3	Pathway
72	Protein Variants
4	Purification (Commentary)
4	Reaction
41	Reference
9	Source Tissue
26	Substrates and Products (Substrate)
8	Subunits
50	Synonyms
1	Systematic Name

Systematic Name

print visible entries

print all entries

Systematic Name on EC 1.17.99.9 - heme a synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

ferroheme o:acceptor C-81-oxidoreductase (heme a-forming)

Contains a heme b cofactor. The enzyme catalyses the conversion of heme o to heme a by two successive hydroxylations of the methyl group at C-8, using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme a [2,4]. The electrons produced by the reaction are transferred to a heme b cofactor [6]. However, the electron acceptor that is used to restore the heme b cofactor to its oxidized state is still not known (both a thioredoxin-like protein and menaquinol have been proposed).