1.17.99.9: heme a synthase
This is an abbreviated version!
For detailed information about heme a synthase, go to the full flat file.
Reaction
Synonyms
ape1694, cCtaA, COX15, COX15p, ctaA, CtaA protein, HAS, TcCox15
ECTree
1.17.99.9 heme a synthaseAdvanced search results
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Natural Substrates Products on EC 1.17.99.9 - heme a synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ferroheme o + H2O + 2 acceptor
ferroheme a + 2 reduced acceptor
overall reaction. The enzyme is involved in biosynthesis of heme A, an obligatory cofactor in eukaryotic cytochrome c oxidase. The enzyme catalyses the conversion of heme o to heme a by two successive hydroxylations of the methyl group at C-8, using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme a
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?
ferroheme o + H2O + 2 acceptor
ferroheme a + 2 reduced acceptor
overall reaction. The enzyme is involved in biosynthesis of heme A, an obligatory cofactor in eukaryotic cytochrome c oxidase. The enzyme catalyses the conversion of heme o to heme a by two successive hydroxylations of the methyl group at C-8, using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme a
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?
