1.17.99.9: heme a synthase
This is an abbreviated version!
For detailed information about heme a synthase, go to the full flat file.
Reaction
Synonyms
ape1694, cCtaA, COX15, COX15p, ctaA, CtaA protein, HAS, TcCox15
ECTree
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Cofactor
Cofactor on EC 1.17.99.9 - heme a synthase
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Ferredoxin
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requirement of ferredoxin and indirectly of ferredoxin reductase in hydroxylation of heme O
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heme a
between 0.2 and 1.95 mol heme B per mol CtaA polypeptide and up to 0.2 mol heme A per mol enzyme (CtaA)
heme
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contains 0.2 mol of heme B per mol of polypeptide, and a small amounts of heme A
between 0.2 and 1.95 mol heme B per mol CtaA polypeptide and up to 0.2 mol heme A per mol enzyme (CtaA)
heme b
two molecules of heme B are bound to the enzyme. Wild-type enzyme contains 54.6 nmol/mg protein. Heme composition of wild-type enzyme hemeB:hemeO:hemeOX:hemeOY is 1.95:0.02:0.03:0. Substitutions of His60 and His126 do not affect heme binding, while His216 and His278 in the carboxy-halves are essential in heme binding