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2.3.1.255: N-terminal amino-acid Nalpha-acetyltransferase NatA

This is an abbreviated version!
For detailed information about N-terminal amino-acid Nalpha-acetyltransferase NatA, go to the full flat file.

Word Map on EC 2.3.1.255

Reaction

acetyl-CoA
+
an N-terminal-glycyl-[protein]
=
an N-terminal-Nalpha-acetyl-glycyl-[protein]
 +
CoA

Synonyms

ARD homolog a, ARD1, ARD1-NAT1 Nalpha-acetyltransferase, ARD1131, ARD1198, ARD1225, ARD1235, Ard1b, ARD1p, ARD2, arrest defective 1, arrest-defective protein 1, arrest-defective protein 1 homologue, AtNAA10, daf-31, DXS707, EC 2.3.1.88, hARD1, hNaa10, hNaa15, hNaa16p, hNat2, More, MtRimI, MUSE6, N(alpha)-acetyltransferase 10, N-alpha-acetyltransferase, N-alpha-acetyltransferase 10, N-alpha-acetyltransferase 11, N-alpha-acetyltransferase 15, N-terminal acetyltransferase, N-terminal acetyltransferase 10, N-terminal acetyltransferase A, N-terminal protein acetyltransferase, NAA10, NAA10-NAA15, NAA10-NAA15 complex, NAA10-NAA15 protein complex, NAA10/ARD1, NAA11, NAA15, Nalpha-acetyltransferase, Nalpha-acetyltransferase 10, NAT, NAT1, NatA, NatA acetyltransferase, NatA Nalpha-terminal acetyltransferase, NatA protein complex, NatA protein Nalpha-terminal-acetyltransferase complex, RimI, RimI acetyltransferase, Rv3420c, SCNaa15, ScNatA, SpNaa10, SpNaa15, SSO0209, Ta0058, Ta1140, TbARD1, TcNatA, TE2, vnc, yNaa10, yNaa15, zNaa10

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.255 N-terminal amino-acid Nalpha-acetyltransferase NatA

Natural Substrates Products

Natural Substrates Products on EC 2.3.1.255 - N-terminal amino-acid Nalpha-acetyltransferase NatA

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + an N-terminal-amino acid-[protein]
an N-terminal-Nalpha-acetyl-amino acid-[protein] + CoA
show the reaction diagram
-
-
-
?
acetyl-CoA + an N-terminal-glycyl-[protein]
an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
show the reaction diagram
acetyl-CoA + an N-terminal-L-alanyl-[protein]
an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
show the reaction diagram
acetyl-CoA + an N-terminal-L-cysteinyl-[protein]
an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
show the reaction diagram
acetyl-CoA + an N-terminal-L-seryl-[protein]
an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
show the reaction diagram
acetyl-CoA + an N-terminal-L-threonyl-[protein]
an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
show the reaction diagram
acetyl-CoA + an N-terminal-L-valyl-[protein]
an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
show the reaction diagram
acetyl-CoA + an N-terminal-lysinyl-[androgen receptor]
an N-terminal-Nalpha-acetyl-lysinyl-[androgen receptor] + CoA
show the reaction diagram
-
ARD1 acetylates androgen receptor at lysine 618
-
-
?
acetyl-CoA + an N-terminal-methionyl-[RPM1 protein]
an N-terminal-Nalpha-acetyl-methionyl-[RPM1 protein] + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + an N-terminal-methionyl-[SNC1 protein]
an N-terminal-Nalpha-acetyl-methionyl-[SNC1 protein] + CoA
show the reaction diagram
-
NatA specifically acetylates the first met of SNC1 protein
-
-
?
acetyl-CoA + beta-catenin
?
show the reaction diagram
-
-
-
-
?
acetyl-CoA + DDDIAAL
CoA + N-acetyl-DDDIAAL
show the reaction diagram
-
-
-
?
acetyl-CoA + EEEIAAL
CoA + N-acetyl-EEEIAAL
show the reaction diagram
best substrate
-
-
?
acetyl-CoA + MLGPEGG
CoA + N-acetyl-MLGPEGG
show the reaction diagram
poor substrate
-
-
?
acetyl-CoA + Orc1p
CoA + Nalpha-acetyl-[Orc1p]
show the reaction diagram
-
Orc1p is the large subunit of the origin recognition complex, ORC. Mechanism for modulating chromaffin function
-
-
?
acetyl-CoA + PCNP protein
CoA + Nalpha-acetyl-PCNP protein
show the reaction diagram
-
i.e. PEST proteolytic signal-containing nuclear protein
-
-
?
acetyl-CoA + peptide
CoA + Nalpha-acetylpeptide
show the reaction diagram
acetyl-CoA + peptide
Nalpha-acetylpeptide + CoA
show the reaction diagram
acetyl-CoA + SESSSKS
CoA + N-acetyl-SESSSKS
show the reaction diagram
-
-
-
?
acetyl-CoA + silencing facor Sir3p
CoA + Nalpha-acetyl-[silencing factor Sir3p]
show the reaction diagram
-
mechanism for modulating chromaffin function
-
-
?
acetyl-CoA + [histone 2B]
an N-terminal-Nalpha-acetyl-[histone 2B] + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + [iso-1-cytochrome c]
an N-terminal-Nalpha-acetyl-[iso-1-cytochrome c] + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + [Runx2]
[Runx2]-N-terminal-N6-acetyl-L-lysine + CoA
show the reaction diagram
NAA10 acetylates Runx2 at Lys225
-
-
?
additional information
?
-
-
endogenous HYPK, a Huntingtin (Htt)-interacting protein, is a stable interactor of NatA, the C terminus of hNaa15p of NatA specifically interacts directly with HYPK, no interaction with hNaa25p of hNatB and hNaa35p of hNatC
-
-
?