2.3.1.255: N-terminal amino-acid Nalpha-acetyltransferase NatA

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For detailed information about N-terminal amino-acid Nalpha-acetyltransferase NatA, go to the full flat file.

Reaction

Synonyms

ARD homolog a, ARD1, ARD1-NAT1 Nalpha-acetyltransferase, ARD1131, ARD1198, ARD1225, ARD1235, Ard1b, ARD1p, ARD2, arrest defective 1, arrest-defective protein 1, arrest-defective protein 1 homologue, AtNAA10, daf-31, DXS707, EC 2.3.1.88, hARD1, hNaa10, hNaa15, hNaa16p, hNat2, More, MtRimI, MUSE6, N(alpha)-acetyltransferase 10, N-alpha-acetyltransferase, N-alpha-acetyltransferase 10, N-alpha-acetyltransferase 11, N-alpha-acetyltransferase 15, N-terminal acetyltransferase, N-terminal acetyltransferase 10, N-terminal acetyltransferase A, N-terminal protein acetyltransferase, NAA10, NAA10-NAA15, NAA10-NAA15 complex, NAA10-NAA15 protein complex, NAA10/ARD1, NAA11, NAA15, Nalpha-acetyltransferase, Nalpha-acetyltransferase 10, NAT, NAT1, NatA, NatA acetyltransferase, NatA Nalpha-terminal acetyltransferase, NatA protein complex, NatA protein Nalpha-terminal-acetyltransferase complex, RimI, RimI acetyltransferase, Rv3420c, SCNaa15, ScNatA, SpNaa10, SpNaa15, SSO0209, Ta0058, Ta1140, TbARD1, TcNatA, TE2, vnc, yNaa10, yNaa15, zNaa10

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.255 N-terminal amino-acid Nalpha-acetyltransferase NatA

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Results	in table
1880	AA Sequence
1	Application
21	Cloned(Commentary)
17	Cofactor
5	Crystallization (Commentary)
66	Disease/ Diagnostics
8	Expression
103	General Information
2	IC50 Value
5	Inhibitors
4	kcat/KM [mM/s]
24	KM Value [mM]
29	Localization
9	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
74	Organism
1	Pathway
10	PDB ID
9	pH Optimum
1	pH Range
2	Posttranslational Modification
57	Protein Variants
14	Purification (Commentary)
6	Reaction
4	Reaction Type
65	Reference
118	Source Tissue
1	Specific Activity [micromol/min/mg]
128	Substrates and Products (Substrate)
26	Subunits
209	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Stability [°C]
23	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.3.1.255 - N-terminal amino-acid Nalpha-acetyltransferase NatA

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

in complex with CoA and with CoA/peptide, sitting drop vapor diffusion method, using 30% (w/v) PEG 4,000, 0.1 M sodium acetate trihydrate, pH 4.6, and 0.2 M (NH4)2SO4 or 5% (w/v) PEG 4,000, 0.1 M sodium acetate trihydrate pH 4.2, and 0.1 M (NH4)2SO4

Saccharolobus solfataricus

Q980R9

730955

holo-NatA complex in the absence and presence of a bisubstrate peptide-CoA-conjugate inhibitor, as well as the uncomplexed Naa10p catalytic subunit, X-ray diffraction structure determination and analysis

Schizosaccharomyces pombe

Q9UTI3; O74985

758492

structure of the 100 kDa holo-NatA complex in the absence and presence of a bisubstrate peptide-CoA conjugate inhibitor, and structure of the uncomplexed Naa10p catalytic subunit. The NatA-Naa15p auxiliary subunit contains 13 TPR motifs and adopts a ring-like topology that wraps around the NatA-Naa10p subunit, an interaction that alters the Naa10p active site for substrate-specific acetylation

Schizosaccharomyces pombe

O74985

736866

hanging drop vapor diffusion method, using 0.1 M sodium acetate pH 4.6, 8% (w/v) polyethylene glycol 4000 and 35% (v/v) glycerol

Thermoplasma acidophilum

Q9HJ33, Q9HM13

739801

hanging drop vapor diffusion method, using 0.1 M trisodium citrate pH 5.6, 20% (v/v) 2-propanol, 20% (w/v) polyethylene glycol 4000 and 0.2 M sodium chloride

Thermoplasma acidophilum

Q9HJ33, Q9HM13

739801