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(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epicatechin gallate
-
-
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(1H-indol-1-yl)(furan-2-yl)methanon
noncompetitive
(1H-indol-1-yl)(furan-2-yl)methanone
noncompetitive inhibitor
(1H-indol-1-yl)(tiyophen-2-yl)methanon
competitive
(1H-indol-1-yl)(tiyophen-2-yl)methanone
competitive inhibitor
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone
-
-
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole
competitive; competitive inhibitor
1-hydroxy-8-methoxy-anthraquinone
inhibition of the enzyme (6PGD) via chemical inhibitor 1-hydroxy-8-methoxy-anthraquinone results in an induction of senescence
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
1H-indol-1-yl(tiyophen-2-yl) methanon
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
2-deoxy-6-phosphono-D-gluconate
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
2-methyl-5-nitrofuran-3-carboxylic acid
-
-
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
-
-
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
3-Oxo-2-deoxy-6-phosphogluconate
-
competitive inhibitor
3-phosphoglycerate
about 40% residual activity at 5 mM
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
4,5-dichloro-1H-pyrrole-2-carboxylic acid
-
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
4-chloro-1H-pyrrole-2-carboxylic acid
-
-
4-phospho-D-erythronamide
4-phospho-D-erythronohydroxamic acid
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
5,6-dideoxy-6-phosphono-D-arabino-hexonate
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
-
-
5-deoxy-5-phosphonoD-arabinonate
5-phospho-D-arabinonamide
5-phospho-D-arabinonhydrazide
5-phospho-D-arabinono-1,4-lactone
5-phospho-D-arabinonohydroxamic acid
6-deoxy-6-phosphono-D-gluconate
6-methoxy-7-hydroxycoumarin
-
scopolin
6-phospho-D-gluconate
-
substrate inhibition
7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
-
NBD-Cl
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
amikacin
-
in vitro inhibition
amikacin sulfate
-
in vitro and in vivo inhibition
amoxicillin
-
competitive
brimonidine
competitive inhibition
ceftazidim
-
in vitro inhibition
chloramphenicol
-
in vitro inhibition
Ciprofloxacin
-
in vitro inhibition
clindamycin
-
competitive
D-5-phosphoribosyl-1-diphosphate
D-6-phosphogluconate
-
competitive substrate inhibition at pH 7
D-fructose 1,6-diphosphate
D-Fructose 1-phosphate
-
-
D-fructose 2,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
D-glucose 6-phosphate
-
-
D-glyceraldehyde 3-phosphate
D-xylulose 5-phosphate
-
-
fructose-1,6-bisphosphate
1 mM, 30% inhibition; 1 mM, 70% decreases in activity
gentamicin sulfate
-
in vitro inhibition
Imipenem
-
noncompetitive
isepamycin
-
in vitro inhibition
levofloxacin
-
in vitro inhibition
lornoxicam
-
noncompetitive
metronidazole
-
noncompetitive
Mg2+
-
acts as an inhibitor above 20 mM
N-(4-chlorobenzoyl) indole
competitive
N-(4-chlorobenzoyl)-indole
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
ofloxacin
-
in vitro inhibition
ornidazole
-
noncompetitive
penicillin G
-
in vitro inhibition
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
physcion
1,8-dihydroxy-3-methoxy-6-methyl-anthrachinon
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
-
-
proparacaine
competitive inhibition
ribose-5-phosphate
1 mM, 29% inhibition; 1 mM, 71% decreases in activity
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
teicoplanin
-
in vitro inhibition
Tetranitromethane
-
irreversible loss of catalytic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
-
-
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
-
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
-
1,5-diphospho-D-ribulose
-
1,5-diphospho-D-ribulose
-
1,5-diphospho-ribitol
-
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
-
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
2-deoxy-6-phosphono-D-gluconate
-
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
-
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
-
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
-
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
-
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
bio-isosteric analogue
4-phospho-D-erythronate
-
-
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
bio-isosteric analogue
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
-
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
conversion of the 6-PGDH inhibitor into prodrugs to increase its activity against the Trypanosoma brucei by enhancing uptake by passive permeation across the plasma membrane. Production of five different phosphate-masking groups (phosphoramidate, bis-S-acyl thioethyl esters, bis-pivaloxymethyl, cycloSaligenyl and phenyl, S-acyl thioethyl mixed phosphate esters). Prodrugs are studied for stability and activity against the intact parasites. Most prodrugs cause inhibition of the growth of the parasites. The activity of the prodrugs against the parasites appears to be related to their stability in aqueous buffer
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythrose
bio-isosteric analogue
4-phospho-D-erythrose
bio-isosteric analogue
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
DTNB
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
Ellman's reagent
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
Ellman's reagent
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
-
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
-
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
-
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
5-deoxy-5-phosphonoD-arabinonate
-
5-deoxy-5-phosphonoD-arabinonate
-
5-phospho-D-arabinonamide
-
5-phospho-D-arabinonamide
-
5-phospho-D-arabinonate
-
5-phospho-D-arabinonate
-
5-phospho-D-arabinonhydrazide
-
5-phospho-D-arabinonhydrazide
-
5-phospho-D-arabinono-1,4-lactone
-
5-phospho-D-arabinono-1,4-lactone
-
5-phospho-D-arabinonohydroxamic acid
-
5-phospho-D-arabinonohydroxamic acid
-
5-phospho-D-arabinose
-
5-phospho-D-ribonate
-
5-phospho-D-ribonate
-
substrate analogue
6-deoxy-6-phosphono-D-gluconate
-
6-deoxy-6-phosphono-D-gluconate
-
6-phospho-D-galactonate
-
6-phospho-D-galactonate
-
6-phosphono-D-mannonate
competitive
6-phosphono-D-mannonate
competitive
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
-
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
-
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
ADP
-
-
ampicillin
-
in vitro inhibition
ampicillin
-
in vitro inhibition
ATP
-
-
ATP
1 mM, 45% inhibition; 1 mM, 55% decreases in activity
Cd2+
-
competitive inhibition
cefepime
-
in vitro inhibition
cefepime
-
in vitro and in vivo inhibition, noncompetitive
citrate
-
-
citrate
1 mM, 16% inhibition; 1 mM, 84% decreases in activity
Cu2+
-
competitive inhibition
D-2-deoxyglucose
-
-
D-5-phosphoribosyl-1-diphosphate
-
-
D-5-phosphoribosyl-1-diphosphate
-
-
D-6-sulfogluconate
-
-
D-erythrose 4-phosphate
-
-
D-erythrose 4-phosphate
-
-
D-erythrose 4-phosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-glyceraldehyde 3-phosphate
-
-
D-glyceraldehyde 3-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
diphosphate
-
-
Fe3+
-
-
Fe3+
noncompetitive inhibition with respect to NADP+ and competitive inhibition with respect to 6-phospho-D-gluconate
Hg2+
-
-
iodoacetamide
-
-
MMV000563
-
MMV000720
-
MMV007199
-
MMV007228
-
MMV007273
-
MMV007384
-
MMV011895
-
MMV665972
-
MMV666125
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N-(4-chlorobenzoyl)-indole
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N-(4-chlorobenzoyl)-indole
competitive inhibitor
N-benzoylindole
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N-benzoylindole
noncompetitive; noncompetitive inhibitor
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
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N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
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NADP+
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substrate inhibition
NADPH
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NADPH
D4ZTT4
competitive inhibitor of NADP+ for wild-type enzyme and non-competitive inhibitor of NADP+ for mutant enzyme T35S; NADPH acts as a competitive inhibitor of NADP+ for the wild-type enzyme and as a non-competitive inhibitor of NADP+ for mutant enzyme T35S
NADPH
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competitive inhibition
NADPH
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noncompetitive inhibition versus 6-phosphogluconate
NADPH
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6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
NADPH
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product inhibition
NADPH
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competitive inhibition
NADPH
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competitive inhibition
NADPH
competitive inhibition versus NADP+ with 6-phospho-D-gluconate equal to its Km and at a saturating concentration
NADPH
saturating concentration at pH 7.5
NADPH
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competitive inhibition
NADPH
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complete inhibition
NADPH
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competitive inhibition
NADPH
0.2 mM, activity markedly decreases, wild-type enzyme shows non-competitive inhibition, mutant enzyme S42T shows competitive inhibition; non-competitive inhibition of wild-type enzyme. Activity markedly decreases to 14% in the presence of 0.2 mM NADPH. Competitive inhibitor of NADP+ in mutant enzyme S42T
NADPH
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competitive inhibition
netilmicin sulfate
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in vitro inhibition
netilmicin sulfate
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in vitro and in vivo inhibition, competitive
netilmicin sulfate
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in vitro and in vivo inhibition
oxaloacetate
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p-chloromercuribenzoate
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p-chloromercuribenzoate
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p-chloromercuribenzoate
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p-chloromercuribenzoate
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p-hydroxymercuribenzoate
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p-hydroxymercuribenzoate
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p-hydroxymercuribenzoate
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phosphate
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competitive inhibitor of the substrates
phosphoenolpyruvate
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phosphoenolpyruvate
1 mM, 36% inhibition; 1 mM, 64% decreases in activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
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compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
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phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
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compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
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compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
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compound shows in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
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compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
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phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
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compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
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compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
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compound shows low in vitro antiparasitic activity
pyridoxal 5'-phosphate
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photooxidation
pyridoxal 5'-phosphate
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pyridoxal 5'-phosphate
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photooxidation
Rose bengal
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photooxidation
Rose bengal
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photooxidation
Rose bengal
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photooxidation
sulfate
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UTP
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Zn2+
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Zn2+
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competitive inhibition
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
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[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
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compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
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compound shows in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
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compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
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compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
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compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
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compound shows low in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
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compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
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compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
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compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
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compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
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compound shows in vitro antiparasitic activity
additional information
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the activityand transcript level of 6PGDH decreases to 67% of its initial activity after 7 days of phosphate starvation
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additional information
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no inhibition by cefozin, decefin, streptomycin, combisid, and meronem
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additional information
not inhibited by fumarate
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additional information
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not inhibited by fumarate
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additional information
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IC50 for antiparasitic activity of inhibitors, overview
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additional information
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not inhibited by ungallated catechins like (-)-epigallocatechin, (-)-gallocatechin, (-)-epicatechin, (-)-catechin, and dehydroepiandrosterone
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additional information
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infection with potato virus Y increases the enzyme activity but decreases the 6-phosphono-D-gluconate content, maximal decrease of 30-50% at period of the highest virus replication
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additional information
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no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
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additional information
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IC50 for antiparasitic activity of inhibitors, overview
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additional information
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ovariectomized rats show a decrease in mRNA level and enzyme activity in the liver, but not in white adipose tissue, which can be restored by 17beta-estradiol administration
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additional information
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IC50 values for antiparasitic activity of inhibitors, overview
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additional information
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IC50 values for antiparasitic activity of inhibitors, overview
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