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Literature summary for 1.1.1.44 extracted from

  • Rodrigues, J.; Branco, V.; Lu, J.; Holmgren, A.; Carvalho, C.
    Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP+-dependent dehydrogenases of the pentose phosphate pathway (2015), Toxicol. Appl. Pharmacol., 286, 216-223.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
ethylmercury
-
 Homo sapiens
Hg2+
-
 Homo sapiens
methylmercury
-
 Homo sapiens
thiomersal
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
 Homo sapiens
6PGDH
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+ dependent on Homo sapiens