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Literature summary for 1.1.1.44 extracted from
- Effects of some antibiotics on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro and in vivo study (2004), J. Enzyme Inhib. Med. Chem., 19, 361-365.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amikacin | in vitro inhibition | Homo sapiens |  |
| ampicillin | in vitro inhibition | Homo sapiens | |
| cefepime | in vitro inhibition | Homo sapiens | |
| cefepime | in vitro and in vivo inhibition, noncompetitive | Rattus norvegicus | |
| ceftazidim | in vitro inhibition | Homo sapiens | |
| chloramphenicol | in vitro inhibition | Homo sapiens | |
| Ciprofloxacin | in vitro inhibition | Homo sapiens | |
| gentamicin sulfate | in vitro inhibition | Homo sapiens | |
| isepamycin | in vitro inhibition | Homo sapiens | |
| levofloxacin | in vitro inhibition | Homo sapiens | |
| additional information | no inhibition by cefozin, decefin, streptomycin, combisid, and meronem | Homo sapiens | |
| netilmicin | - |
Rattus norvegicus | |
| netilmicin sulfate | in vitro inhibition | Homo sapiens | |
| netilmicin sulfate | in vitro and in vivo inhibition, competitive | Rattus norvegicus | |
| ofloxacin | in vitro inhibition | Homo sapiens | |
| penicillin G | in vitro inhibition | Homo sapiens | |
| teicoplanin | in vitro inhibition | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phosphono-D-gluconate + NADP+ | Homo sapiens | - |
D-ribulose 5-phosphate + CO2 + NADPH | - |
? | |
| 6-phosphono-D-gluconate + NADP+ | Rattus norvegicus | - |
D-ribulose 5-phosphate + CO2 + NADPH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 725.4fold from erythrocytes by ammonium sulfate precipitation, 2',5'-ADP-resin affinity chromatography, and gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.89 | - |
purified enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phosphono-D-gluconate + NADP+ | - |
Homo sapiens | D-ribulose 5-phosphate + CO2 + NADPH | - |
? | |
| 6-phosphono-D-gluconate + NADP+ | - |
Rattus norvegicus | D-ribulose 5-phosphate + CO2 + NADPH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphogluconate dehydrogenase | - |
Homo sapiens |
| 6-phosphogluconate dehydrogenase | - |
Rattus norvegicus |
| 6PGD | - |
Homo sapiens |
| 6PGD | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
| 25 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
| 8 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
| NADP+ | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.939 | - |
netilmicin | pH 8.0, 25°C | Rattus norvegicus | |
| 2.579 | - |
cefepime | pH 8.0, 25°C | Rattus norvegicus | |
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