1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) This is an abbreviated version! For detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file .
Reaction
6-phospho-D-gluconate +
NADP+ =
D-ribulose 5-phosphate +
CO2 +
NADPH +
H+
Synonyms 6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase 1, 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, 6PGDH1, 6PGDH2, 6PGDH3, At1G64190, At3g02360, At5g41670, D-gluconate-6-phosphate dehydrogenase, GCG1, gnd, GND1, Gnd1p, Gnd2p, GNTZII, LlPDH, Moth_1283, Os6PGDH1, Os6PGDH2, p6PGDH, peroxisomal 6-phosphogluconate dehydrogenase, Pgd, PGD1, PGD2, PGD3, phosphogluconic acid dehydrogenase, TM0438, YpjI, zwf3
ECTree
Source Tissue
Source Tissue on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
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low activity in female and male rats, constant at age 2 months to age 9 months
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high activity in female and male rats, decreasing from age 2 months to age 9 months
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infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD)
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high enzyme expression level
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highest activity in outer leaf sheaths and lowest in inner leaf sheaths
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from spleen, lymph node or thymus
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the enzyme is upregulated during salt stress
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antibodies to 6-phosphogluconate dehydrogenase, decarboxylating are present in serum samples of ASA-positive (antisperm antibodies) infertile men
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stably expressing epidermal growth factor receptor (EGFR), infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD)
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moderate activity in female and male rats, decreasing from age 2 months to age 9 months
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additional information
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enzyme mRNA concentration show age- and sex-related differences, especially in the liver, overview
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a 6PGD gene expression pattern in ovines differing in weight is not followed by analogous changes of its enzymatic activity suggesting that other post transcription or post translation regulation is involved
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low enzyme expression level
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286834 , 286836 , 286837 , 286838 , 286839 , 286841 , 286849 , 286850 , 286881 , 286890 , 286892 , 286895 , 286897 , 286903 , 656386 brenda
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epididymal
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low activity in female and male rats, constant at age 2 months to age 9 months
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nicotine has no effect on enzyme activity
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cortex
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cortex, low activity in female and male rats, decreasing from age 2 months to age 9 months
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cortex
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very low enzyme expression level
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286836 , 286837 , 286838 , 286839 , 286846 , 286849 , 286850 , 286881 , 286890 , 286892 , 286895 , 286903 brenda
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286827 , 286829 , 286830 , 286831 , 286833 , 286837 , 286838 , 286840 , 286844 , 286849 , 286850 , 286852 , 286855 , 286862 , 286871 , 286872 , 286875 , 286881 , 286883 , 286884 , 286890 , 286892 , 286894 , 286898 , 286901 , 286902 , 286903 , 286904 , 286987 , 656470 , 696246 brenda
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286827 , 286829 , 286833 , 286836 , 286838 , 286840 , 286846 , 286849 , 286850 , 286859 , 286863 , 286868 , 286882 , 286892 , 286895 , 668323 , 740634 brenda
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moderate activity in female and male rats, decreasing from age 2 months to age 9 months
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nicotine has no effect on enzyme activity. Vitamin E may favourably increase 6PGD activity
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nicotine activates enzyme activity, increase in activity is eliminated by vitamin E
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leg and skeletal
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nicotine activates enzyme activity, when administered with vitamin E the increase in enzyme activity is lower
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low enzyme expression level
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low expression
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3-leaf stage
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transcript levels of both Os6PGDH1 and Os6PGDH2 are up-regulated in rice seedlings under drought, cold, high salinity and abscisic acid treatments
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low activity in female and male rats, constant at age 2 months to age 9 months
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nicotine activates enzyme activity, when administered with vitamin E the increase in enzyme activity is lower
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