EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.96 | diiodophenylpyruvate reductase |
brain |
- |
287552, 287553, 287554 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
brain |
11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone |
654196 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
brain |
11HSD1 is highly expressed in various brain structures, including the hippocampus |
743428 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
brain |
almost no expression and activity |
695148 |
1.1.3.17 | choline oxidase |
brain |
- |
740194 |
1.1.3.8 | L-gulonolactone oxidase |
brain |
no significant changes in mRNA expression levels and protein abundances of gulo/Gulo in the brain during estivation and arousal, overview |
742475 |
1.1.5.13 | (S)-2-hydroxyglutarate dehydrogenase |
brain |
- |
755232 |
1.1.5.3 | glycerol-3-phosphate dehydrogenase |
brain |
- |
-, 287802, 287806, 287809, 287812, 690606, 741302 |
1.1.99.2 | L-2-hydroxyglutarate dehydrogenase |
brain |
low level |
657168 |
1.1.99.24 | hydroxyacid-oxoacid transhydrogenase |
brain |
- |
-, 287797 |
1.1.99.24 | hydroxyacid-oxoacid transhydrogenase |
brain |
low enzyme activity |
664967 |
1.10.3.1 | catechol oxidase |
brain |
- |
657987 |
1.10.3.5 | 3-hydroxyanthranilate oxidase |
brain |
- |
-, 389980, 389981 |
1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) |
brain |
- |
659111 |
1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) |
brain |
minimal expression |
657888, 658430 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
brain |
- |
-, 394866, 394867, 394871, 671327, 674370, 674598, 697470, 764701, 765297 |
1.11.1.20 | prostamide/prostaglandin F2alpha synthase |
brain |
- |
687797, 740108, 741103 |
1.11.1.20 | prostamide/prostaglandin F2alpha synthase |
brain |
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs |
687797 |
1.11.1.20 | prostamide/prostaglandin F2alpha synthase |
brain |
highest activity in the spinal cord and brain |
687797 |
1.11.1.20 | prostamide/prostaglandin F2alpha synthase |
brain |
the enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies. The enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons. At the ultrastructural level, the enzyme is localized to myelin sheaths. Expression of the enzyme increases between postnatal day 9 and postnatal day 14 during the postnatal development, presumably in accordance with myelinogenesis |
707934 |
1.11.1.24 | thioredoxin-dependent peroxiredoxin |
brain |
0.0013 mg Prx I per mg of soluble protein Prx I, 0.0013 mg Prx II per mg of soluble protein, 0.0005 mg Prx III per mg of soluble protein, 0.001 mg Prx V per mg of soluble protein and 0.0017 mg Prx VI per mg of soluble protein |
655756 |
1.11.1.27 | glutathione-dependent peroxiredoxin |
brain |
- |
710899 |
1.11.1.6 | catalase |
brain |
- |
700588 |
1.11.1.6 | catalase |
brain |
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart |
744948 |
1.11.1.9 | glutathione peroxidase |
brain |
- |
695604, 712067, 764392, 765409 |
1.11.1.9 | glutathione peroxidase |
brain |
activity in brain is much lower than in liver |
677215 |
1.11.1.9 | glutathione peroxidase |
brain |
highest expression |
725061 |
1.11.1.9 | glutathione peroxidase |
brain |
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart |
744948 |
1.11.1.9 | glutathione peroxidase |
brain |
highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain |
724102 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
brain |
- |
743064 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
brain |
constitutively expressed |
764295 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
brain |
expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes |
743358 |
1.13.11.19 | cysteamine dioxygenase |
brain |
Cysteamine levels in brain of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have markedly elevated levels of hypotaurine in brain. |
671185 |
1.13.11.19 | cysteamine dioxygenase |
brain |
high activity |
687595 |
1.13.11.19 | cysteamine dioxygenase |
brain |
hypotaurine is not in brain of either Vanin-1 (+/+) or Vanin-1 (-/-) mice that had been fed a non-purified rodent diet. |
671185 |
1.13.11.20 | cysteine dioxygenase |
brain |
- |
439557, 657523, 742253 |
1.13.11.20 | cysteine dioxygenase |
brain |
barely detectable levels |
439556 |
1.13.11.20 | cysteine dioxygenase |
brain |
lower level than in liver |
657515 |
1.13.11.20 | cysteine dioxygenase |
brain |
neuron, including the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum, the regional localization varies, with high levels of expression in the hippocampus, the dentate gyrus, the outer cortices of the brain, and the substantia nigra |
439555 |
1.13.11.31 | arachidonate 12-lipoxygenase |
brain |
- |
659765 |
1.13.11.31 | arachidonate 12-lipoxygenase |
brain |
12/15-LOX is selectively enhanced in the periphery, 12/15-LOX-expressing myeloid cells are enriched in the brain during chronic toxoplasmosis |
-, 704003 |
1.13.11.31 | arachidonate 12-lipoxygenase |
brain |
increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain |
-, 743056 |
1.13.11.31 | arachidonate 12-lipoxygenase |
brain |
the 12/15-LOX metabolic pathway is increased and correlates with an oxidative imbalance in the Alzheimers disease brain, implying that this enzyme might contribute to the pathogenesis of this neurodegenerative disorder |
657508 |
1.13.11.33 | arachidonate 15-lipoxygenase |
brain |
- |
742613 |
1.13.11.33 | arachidonate 15-lipoxygenase |
brain |
12/15-LOX is selectively enhanced in the periphery, 12/15-LOX-expressing myeloid cells are enriched in the brain during chronic toxoplasmosis |
-, 704003 |
1.13.11.33 | arachidonate 15-lipoxygenase |
brain |
increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain |
-, 743056 |
1.13.11.34 | arachidonate 5-lipoxygenase |
brain |
- |
439477, 684399, 690170, 742314 |
1.13.11.34 | arachidonate 5-lipoxygenase |
brain |
of young and old mice, comparison of enzyme expression and activity in brain regions, e.g. cortex, hippocampus and cerebellum, overview |
-, 689167 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
brain |
expression of HGO gene |
439388 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
- |
395466, 395499, 665457, 666461, 666895, 671714, 726042, 743064 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
activity with D-Trp and L-Trp |
395480 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
Alzheimer's disease brain |
726330 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
enzyme activity in triple transgenic Alzheimer's disease mice. Expression of TDO mRNA is significantly increased in the cerebellum of Alzheimer's disease mouse brain |
726330 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes |
743358 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
IDO-1 is associated with senile plaques in Alzheimer's disease brains and is specifically localized in conjunction with neurofibrillary tangles |
713489 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
IDO2 |
723923 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
in the group of rats aged 12 months, the highest specific activity is found in the small intestine |
674079 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
indoleamine 2,3-dioxygenase |
395466 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
brain |
microvascular endothelial cell, HBMEC |
665164 |
1.13.11.6 | 3-hydroxyanthranilate 3,4-dioxygenase |
brain |
- |
439373, 439378 |
1.13.11.6 | 3-hydroxyanthranilate 3,4-dioxygenase |
brain |
regional distribution |
439366 |
1.13.11.6 | 3-hydroxyanthranilate 3,4-dioxygenase |
brain |
relatively small amounts |
439367 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
brain |
- |
438236, 713952 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
brain |
adult and embryonic, very low Bco1 expression level |
744160 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
brain |
- |
719151, 745596 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
brain |
embryonic, low Bco2 expression level |
744160 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
brain |
low abundance of mRNA |
719806 |
1.14.11.1 | gamma-butyrobetaine dioxygenase |
brain |
- |
672375, 697453, 699163 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
brain |
- |
439251 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
brain |
- |
439239, 659235 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
brain |
expression of alpha-I and alpha-II subunits mRNAs |
439239 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
brain |
expression of enzyme alpha-I subunit mRNA |
439242 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
brain |
- |
741826, 743581 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
brain |
expression level of of HIF-P4H-3 mRNA is highest in the adult heart, brain, placenta, lung, and skeletal muscle and in the fetal heart, spleen, and skeletal muscle |
659235 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
brain |
the level of HIF-P4H-1 mRNA expression is highest in the adult brain, placenta, lung, and kidney |
659235 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
brain |
the levels of HIF-P4H-2 mRNA expression is highest in the adult heart, brain, lung, and liver and in the fetal brain, heart, spleen, and skeletal muscle |
659235 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
brain |
- |
657744, 675031, 724792 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
brain |
PLOD2 is mainly expressed within the tunica media of the blood vessels |
746556 |
1.14.11.53 | mRNA N6-methyladenine demethylase |
brain |
highly expressed during the embryonic development of the brain and decreases in the late brain development |
764386 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
brain |
- |
744236, 744861 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
brain |
high basal expression with 2.3-fold increase in mRNA after 6 h of hypoxia |
684929 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
brain |
high expression level |
744861 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
brain |
- |
754910 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
brain |
- |
756363 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
brain |
the distributions of H3-K4 mono-, di-, and tri-methylated histones exhibit exactly the same pattern as the LSD1 protein, immunofluoresecence histochemic analysis, overview |
-, 713122 |
1.14.11.7 | procollagen-proline 3-dioxygenase |
brain |
isozyme P3H3 |
697189 |
1.14.11.8 | trimethyllysine dioxygenase |
brain |
- |
675029 |
1.14.11.B19 | [histone H3]-trimethyl-L-lysine56 demethylase |
brain |
low expression level |
755194 |
1.14.13.29 | 4-nitrophenol 2-monooxygenase |
brain |
- |
673929 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
- |
-, 440190, 440191, 440192, 440196, 440197, 440198, 440199, 440203, 440205, 440210, 440211, 440212, 440213, 440220, 440224, 440226, 440228, 440232, 440236, 440239, 671278, 672524, 674558, 686010, 686293, 697042, 700432, 711779, 744948, 765779 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
Ca2+-dependent isoform |
-, 440194, 440202 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
from rats with unilateral depletion of dopamine in the substantia nigra compacta treated with L-DOPA at 30 mg/kg body weight for 34 days, nNOS expression is restricted to neurons |
-, 711646 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
hypothalamic paraventricular nucleus and tanycytes |
-, 763849 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
isoform I |
440226 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
neuronal enzyme |
671728 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
nNOS |
685120 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
nNOS is the predominant isozyme in brain |
695853 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
brain |
visual cortex, use of the NADPH-d histochemistry technique to evaluate the expression of NOS across the nervous system |
-, 764565 |
1.14.13.8 | flavin-containing monooxygenase |
brain |
- |
348503, 658482, 673313, 676315, 712902, 764558 |
1.14.13.9 | kynurenine 3-monooxygenase |
brain |
- |
-, 348521, 675556, 689224, 742349, 763915, 764034, 764296, 764298, 765436 |