EC Number   |
Recommended Name |
Source Tissue |
Reference |
|---|
   7.2.2.10 | P-type Ca2+ transporter |
brain |
PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine. The PMCA3 and PMCA4 pumps are expressed in brain, the PMCA2 pump is a brain isoform. |
695858 |
| 7.2.2.10 | P-type Ca2+ transporter |
brain |
predominant expression of splice variant PMCA4e |
734295 |
| 7.2.2.10 | P-type Ca2+ transporter |
brain |
synaptosomes |
210476 |
| 7.2.2.10 | P-type Ca2+ transporter |
brain |
the PMCA2 pump is a brain isoform |
695858 |
| 7.2.2.10 | P-type Ca2+ transporter |
brain |
the PMCA3 pump is expressed in brain |
695858 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
- |
246950, 246958, 246962, 246963, 246964, 246966, 246969, 246972, 656021, 685891, 711650, 713007, 713011, 733681, 735111, 735302, 750350 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
capillary endothelium |
246966 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
cerebral cortex |
710778 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
cerebral, ipsilateral cortex |
711638 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
cortex |
246962, 711636 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
little changes in enzyme alpha subunit isoform composition between summer and winter. Exposure to anoxia does not affect the activity of Na+K+-ATPase, but there is a 150fold extension in brain anoxia tolerance by seasonal changes in energy supply-demand ratio. Enzyme shows 10times lower catalytic activity in winter than in summer |
684362 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
mainly alpha2- and alpha3 isoform |
700691 |
| 7.2.2.13 | Na+/K+-exchanging ATPase |
brain |
neocortex |
713111 |
| 7.2.2.14 | P-type Mg2+ transporter |
brain |
- |
695972, 696596, 698035 |
| 7.2.2.19 | H+/K+-exchanging ATPase |
brain |
limbic system and cerebellum |
713552 |
| 7.2.2.8 | P-type Cu+ transporter |
brain |
- |
733097 |
| 7.2.2.8 | P-type Cu+ transporter |
brain |
select areas of the brain, including the developing central nervous system |
734662 |
| 7.2.2.9 | P-type Cu2+ transporter |
brain |
- |
246908, 246909 |
| 7.2.2.9 | P-type Cu2+ transporter |
brain |
ATP7A expression is most abundant in the early postnatal period, reaching peak levels at P4 in neocortex and cerebellum. In the developing and adult brain, ATP7A levels are greatest in the choroid plexus/ependymal cells of the lateral and third ventricles. ATP7A expression decreases in most neuronal subpopulations from birth to adulthood. ATP7A expression increases in CA2 hippocampal pyramidal and cerebellar Purkinje neurons |
670415 |
| 7.2.2.9 | P-type Cu2+ transporter |
brain |
ATP7A is widely expressed throughout the CNS |
712175 |
| 7.2.2.9 | P-type Cu2+ transporter |
brain |
expression of ATP7A, not of ATP7B |
713537 |
| 7.2.2.9 | P-type Cu2+ transporter |
brain |
intensely detected in neuronal cells of the hippocampal formation, olfactory bulbs, cerebellum, cerebral cortex and nuclei in the brainstem |
246911 |
| 7.3.2.2 | ABC-type phosphonate transporter |
brain |
- |
289158 |
| 7.6.2.1 | P-type phospholipid transporter |
brain |
- |
246839, 246845, 685854, 733778, 749361 |
| 7.6.2.1 | P-type phospholipid transporter |
brain |
low distribution in brain |
696442 |
| 7.6.2.1 | P-type phospholipid transporter |
brain |
synaptosomes |
246839 |
| 7.6.2.1 | P-type phospholipid transporter |
brain |
the ATP10C demonstrates imprinted, preferential maternal expression in brain |
654164 |
| 7.6.2.2 | ABC-type xenobiotic transporter |
brain |
- |
670003, 695397, 697587, 733776, 747448 |
| 7.6.2.2 | ABC-type xenobiotic transporter |
brain |
MRP4 is mainly expressed in the luminal membrane of capillary endothelium, but also in the basolateral membrane of choroid plexus and in astrocytes |
701356 |
| 7.6.2.3 | ABC-type glutathione-S-conjugate transporter |
brain |
- |
748624, 749410 |
| 7.6.2.4 | ABC-type fatty-acyl-CoA transporter |
brain |
- |
689002, 696484 |
