EC Number |
General Information |
Reference |
---|
5.6.2.3 | evolution |
ChlR1 is a superfamily 2 DNA helicase that contains a conserved iron-sulfur domain. In humans exist four iron-sulfur DNA helicases, XPD, FANCJ, RTEL1, and ChlR1, that are implicated in autosomal recessive genetic diseases |
734320 |
5.6.2.3 | evolution |
DNA helicase B is a robust 5'-3' superfamily I DNA helicase conserved among vertebrates |
758118 |
5.6.2.3 | evolution |
DNA/RNA helicases are classified into six superfamilies (SF1e6) defined by a set of conserved sequence motifs. Tk-Upf1 is a superfamily 1B type helicase |
-, 755962 |
5.6.2.3 | evolution |
DnaB are considered to be members of the RecA superfamily. All members of this superfamily, including DnaB, have a conserved C-terminal domain, known as the RecA core. DnaB helicases of the DnaB helicase family may have evolved from single domain RecA core proteins having helicase activities of their own, through the incorporation of additional N-terminal sequences. The helicases can be classified into six super-families of which DnaB which is the replicative helicase in Eubacteria, belongs to Superfamily 4. DnaB helicases are characteristically hexameric in structure. phylogenetic and evolutionary analysis identifies WCGp80 to be related to an ancestor of DnaB helicase family proteins |
735032 |
5.6.2.3 | evolution |
HELQ is a superfamily II DNA helicase |
757877 |
5.6.2.3 | evolution |
hPIF1 belongs to the evolutionarily conserved Pif1 family, which comprises multifunctional helicases with a unique 21 amino acid signature motif. Pfh1 is the sole Sschizosaccharomyces pombe Pif1 member |
-, 757837 |
5.6.2.3 | evolution |
phylogenetic analysis of amino acid sequences of Twinkle homologues from several plants and other species shows that the Arabidopsis and plant homologues are closely clustered and are most similar to the bacteriophage T7 gp4 protein |
733586 |
5.6.2.3 | evolution |
Pif1 family helicases are found in the genomes of organisms from all three kingdoms. Most eukaryotes, including Schizosaccharomyces pombe and humans, encode a single Pif1 family helicase, while Saccharomyces cerevisiae encodes two, ScPif1 and ScRrm3 |
-, 756286 |
5.6.2.3 | evolution |
Sen1p is a nuclear superfamily 1 RNA/DNA helicase |
756719 |
5.6.2.3 | evolution |
superfamilies 1 and 2 (SF1 and SF2) comprise the largest number of helicase families and members are involved in a wide array of cellular functions that require manipulation of DNA or RNA structures, the helicases belong to the AAA+ ATPases. Helicase superfamilies can also be subdivided into those that translocate along DNA and unwind in a 3'-5' direction, e.g., SF1A, or a 5'-3 direction, e.g., SF1B. SF1 and SF2 helicases can be identified based on evolutionary conservation of seven sequence motifs (I, Ia, II-VI) that are required for ATP binding/hydrolysis, nucleic acid binding, and/or translocation. SF1 and SF2 helicases include a conserved core helicase domain that is comprised of two subdomains that share similarity with RecA ATPase/recombinase enzyme family |
735221 |