Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.3 extracted from

  • Li, Y.P.; Yang, J.J.; Xu, H.; Guo, E.Y.; Yu, Y.
    Structure-function analysis of DNA helicase HELQ a new diagnostic marker in ovarian cancer (2016), Oncol. Lett., 12, 4439-4444 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.3

Application

Application Comment Organism
diagnostics DNA helicase HELQ is a marker for ovarian cancer Homo sapiens
medicine modulation the function of HELQ helicase may be used in the treatment of ovarian cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Homo sapiens 5743
-
mitochondrial matrix
-
 Homo sapiens 5759
-
additional information subcellular localization analysis, overview Homo sapiens
-
-
nucleus mainly Homo sapiens 5634
-
peroxisome
-
 Homo sapiens 5777
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TDG4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary
-
 Homo sapiens
-
ovary cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
More analysis of the secondary structure of the HELQ protein and functional domain, overview. HELQ is mainly composed of alpha-helixes (46.48%) and random coils (43.05%), with extended strands accounting for only 10.26% of the structure Homo sapiens

Synonyms

Synonyms Comment Organism
ATP-dependent helicase
-
 Homo sapiens
DNA helicase HELQ
-
 Homo sapiens
helicase POLQ-like UniProt Homo sapiens
HELQ
-
 Homo sapiens

General Information

General Information Comment Organism
evolution HELQ is a superfamily II DNA helicase Homo sapiens
malfunction deficiency of the helicase, POLQ-like (HELQ) gene increases the risk of ovarian cancer Homo sapiens
additional information structure-function analysis of DNA helicase HELQ, overview. Three-dimensional ligand binding model, the ligand binding sites are distributed over Ile333, Lys335, Tyr337, Gln340, Ser362, Gly363, Gly364, Lys365, Thr366, Leu367, Lys397, and Asn678 Homo sapiens
physiological function the dominant functions of HELQ are ATP-dependent helicase activity and participation in the DNA repair process. Analysis of the role of HELQ in DNA replicaxadtion, DNA repair and maintenance of genomic stability. Molecular function ontology of HELQ, overview Homo sapiens