EC Number |
General Information |
Reference |
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3.4.22.16 | physiological function |
CatB3 is a major protease antigen in Fasciola gigantica metacercariae and newly excysted juveniles |
707007 |
3.4.22.16 | malfunction |
lymphocytes deficient in CatH are still capable of generating active granzyme B. CatH-deficient mice do not show a gross morphological phenotype and no impairment of reproductive capacity or breeding behavior or nursing |
709114 |
3.4.22.16 | malfunction |
cathepsin H-deficient mice show no gross phenotype and their development is normal without growth retardation. Broncho-alveolar lavage from cathepsin H-deficient mice contain lower levels of pulmonary surfactant protein B |
718296 |
3.4.22.16 | physiological function |
cathepsin H is involved in the surfactant protein B production |
718296 |
3.4.22.16 | malfunction |
specific inhibition of cathepsin H increases the activation of alphabeta3-integrin on PC-3 cells |
732111 |
3.4.22.16 | physiological function |
cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells |
732111 |
3.4.22.16 | malfunction |
knockout of the cathepsin H gene results in 50% reduction of (Met)enkephalin in mouse brain. Cathepsin H deficient mice also show a substantial 80% decrease in galanin peptide neurotransmitter levels in brain |
732360 |
3.4.22.16 | physiological function |
cathepsin H plays a role in enkephalin and galanin peptide neurotransmitter production |
732360 |
3.4.22.16 | malfunction |
loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout |
753961 |
3.4.22.16 | malfunction |
reduced filaggrin processing and impaired epidermal barrier in CTSH-deficient mouse skin, histology of Ctsh-/-, Ctsh+/-, and wild-type mouse neonatal skin, overview. Loss of CTSH increases skin macrophage counts, mast cell degranulation, and proinflammatory molecule expression. Loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout |
-, 753961 |