EC Number   |
General Information |
Reference |
|---|
   3.4.22.16 | physiological function |
CatB3 is a major protease antigen in Fasciola gigantica metacercariae and newly excysted juveniles |
707007 |
| 3.4.22.16 | evolution |
cathepsin H is a member of the papain superfamily of lysosomal cysteine proteases |
755176 |
| 3.4.22.16 | physiological function |
cathepsin H is involved in the surfactant protein B production |
718296 |
| 3.4.22.16 | physiological function |
cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells |
732111 |
| 3.4.22.16 | physiological function |
cathepsin H plays a role in enkephalin and galanin peptide neurotransmitter production |
732360 |
| 3.4.22.16 | malfunction |
cathepsin H-deficient mice show no gross phenotype and their development is normal without growth retardation. Broncho-alveolar lavage from cathepsin H-deficient mice contain lower levels of pulmonary surfactant protein B |
718296 |
| 3.4.22.16 | malfunction |
knockout of the cathepsin H gene results in 50% reduction of (Met)enkephalin in mouse brain. Cathepsin H deficient mice also show a substantial 80% decrease in galanin peptide neurotransmitter levels in brain |
732360 |
| 3.4.22.16 | malfunction |
loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout |
753961 |
| 3.4.22.16 | malfunction |
lymphocytes deficient in CatH are still capable of generating active granzyme B. CatH-deficient mice do not show a gross morphological phenotype and no impairment of reproductive capacity or breeding behavior or nursing |
709114 |
| 3.4.22.16 | metabolism |
phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation |
-, 753961 |
