Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.16 extracted from

  • Buehling, F.; Kouadio, M.; Chwieralski, C.E.; Kern, U.; Hohlfeld, J.M.; Klemm, N.; Friedrichs, N.; Roth, W.; Deussing, J.M.; Peters, C.; Reinheckel, T.
    Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice (2011), PLoS ONE, 6, e26247.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
x * 25000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
surfactant protein B + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney highest activity is detected in the kidney Mus musculus
-
liver
-
Mus musculus
-
lung
-
Mus musculus
-
pneumocyte cathepsin H is highly expressed in the secretory organelles of alveolar type II pneumocytes Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg-7-amido-4-methylcoumarin + H2O specific substrate Mus musculus L-Arg + 7-amino-4-methylcoumarin
-
?
surfactant protein B + H2O
-
Mus musculus ?
-
?

Subunits

Subunits Comment Organism
? x * 25000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
CTSH
-
Mus musculus

General Information

General Information Comment Organism
malfunction cathepsin H-deficient mice show no gross phenotype and their development is normal without growth retardation. Broncho-alveolar lavage from cathepsin H-deficient mice contain lower levels of pulmonary surfactant protein B Mus musculus
physiological function cathepsin H is involved in the surfactant protein B production Mus musculus