Cloned (Comment) | Organism |
---|---|
gene CTSH, real-time PCR enzyme expression analysis in skin and keratinocyte culture | Homo sapiens |
gene CTSH, real-time PCR enzyme expression analysis in skin and keratinocyte culture | Mus musculus |
gene CTSH, real-time PCR enzyme expression analysis in skin and keratinocyte culture | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of short hairpin RNA Ctsh knockout and heterozygote mice into C57BL/6J background | Mus musculus |
additional information | lentiviral shRNA knockdown in human keratinocytes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
lysosome | - |
Mus musculus | 5764 | - |
lysosome | - |
Rattus norvegicus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09668 | - |
- |
Mus musculus | P49935 | - |
- |
Mus musculus C57BL/6J | P49935 | - |
- |
Rattus norvegicus | P00786 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | - |
Homo sapiens | - |
keratinocyte | - |
Mus musculus | - |
keratinocyte | epidermal | Rattus norvegicus | - |
additional information | immunofluorescent and immunohistochemic analysis | Homo sapiens | - |
additional information | immunofluorescent and immunohistochemic analysis | Mus musculus | - |
additional information | immunofluorescent and immunohistochemic analysis | Rattus norvegicus | - |
skin | - |
Homo sapiens | - |
skin | - |
Mus musculus | - |
skin | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
CTSH | - |
Homo sapiens |
CTSH | - |
Mus musculus |
CTSH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout | Homo sapiens |
malfunction | loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout | Rattus norvegicus |
malfunction | reduced filaggrin processing and impaired epidermal barrier in CTSH-deficient mouse skin, histology of Ctsh-/-, Ctsh+/-, and wild-type mouse neonatal skin, overview. Loss of CTSH increases skin macrophage counts, mast cell degranulation, and proinflammatory molecule expression. Loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout | Mus musculus |
metabolism | phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation | Homo sapiens |
metabolism | phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation | Mus musculus |
metabolism | phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation | Rattus norvegicus |
physiological function | profilaggrin to filaggrin processing is complex, requiring dephosphorylation and numerous proteolytic events, several proteases have been identified that cleave profilaggrin at specific sites, releasing the filaggrin monomers and both the N- and C-termini, including cathepsin H. CTSH is a differentiation-dependent protease coexpressed with filaggrin | Homo sapiens |
physiological function | profilaggrin to filaggrin processing is complex, requiring dephosphorylation and numerous proteolytic events, several proteases have been identified that cleave profilaggrin at specific sites, releasing the filaggrin monomers and both the N- and C-termini, including cathepsin H. CTSH is a differentiation-dependent protease coexpressed with filaggrin | Mus musculus |
physiological function | profilaggrin to filaggrin processing is complex, requiring dephosphorylation and numerous proteolytic events, several proteases have been identified that cleave profilaggrin at specific sites, releasing the filaggrin monomers and both the N- and C-termini, including cathepsin H. CTSH is a differentiation-dependent protease coexpressed with filaggrin | Rattus norvegicus |