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EC 1.14.19.20 Details
show Brenda entryEC number
1.14.19.20
Accepted name
Δ7-sterol 5(6)-desaturase
Reaction
a Δ7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a Δ5,7-sterol + 2 ferricytochrome b5 + 2 H2O
Other name(s)
lathosterol oxidase,
Δ7-sterol Δ5-dehydrogenase,
Δ7-sterol 5-desaturase,
Δ7-sterol-C5(6)-desaturase,
5-DES,
SC5DL (gene name),
ERG3 (gene name)
Systematic name
Δ7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating
CAS registry number
37255-37-1
Comment
This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Δ7-sterols, to yield the corresponding Δ5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.
History
created 1972 as EC 1.3.3.2, transferred 2005 to EC 1.14.21.6, transferred 2015 to EC 1.14.19.20
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000 1.14.99.6 created 1972, modified 2000, deleted 2000 1.14.99.8 created 1972, deleted 1984 1.14.99.13 created 1972, deleted 1984 1.14.99.16 created 1972, deleted 2002 1.14.99.17 created 1972, deleted 1976 1.14.99.18 created 1976, modified 1999, deleted 2003 1.14.99.25 created 1986, deleted 2000
