EC Explorer

1.14.19.6

acyl-CoA (9+3)-desaturase

(1) oleoyl-CoA + 2 ferrocytochrome b₅ + O₂ + 2 H⁺ = linoleoyl-CoA + 2 ferricytochrome b₅ + 2 H₂O;;(2) palmitoleoyl-CoA + 2 ferrocytochrome b₅ + O₂ + 2 H⁺ = (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b₅ + 2 H₂O

oleoyl-CoA 12-desaturase, Δ¹² fatty acid desaturase, Δ¹²(ω⁶)-desaturase, oleoyl-CoA Δ¹² desaturase, Δ¹² desaturase, Δ¹²-desaturase, Δ¹²-fatty-acid desaturase, acyl-CoA,hydrogen donor:oxygen Δ¹²-oxidoreductase

acyl-CoA,ferrocytochrome b₅:oxygen oxidoreductase (12,13 cis-dehydrogenating)

This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Δ¹⁰ fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b₅ as the electron donor [4].

created 2008, modified 2015