2.7.1.36: mevalonate kinase
This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.
Word Map on EC 2.7.1.36
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2.7.1.36
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fever
-
autoinflammatory
-
cholesterol
-
isoprenoids
-
mediterranean
-
aciduria
-
hereditary
-
receptor-associated
-
hyperimmunoglobulinemia
-
vinyl
-
ketone
-
cryopyrin-associated
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phosphomevalonate
-
febrile
-
igd
-
isopentenyl
-
monogenic
-
farnesyl
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tnfrsf1a
-
isoprene
-
hyper-igd
-
anakinra
-
rash
-
lymphadenopathy
-
hmg-coa
-
inflammasome
-
geranylgeranylation
-
amyloidosis
-
aphthous
-
porokeratosis
-
arthralgia
-
non-sterol
-
pyoderma
-
nod2
-
papa
-
autoinflammation
-
gangrenosum
-
canakinumab
-
adenitis
-
pstpip1
-
hyperimmunoglobulin
-
medicine
-
hepatosplenomegaly
-
cholesterogenesis
-
etanercept
-
cryopyrin
-
synthesis
-
diagnostics
- 2.7.1.36
- fever
- autoinflammatory
- cholesterol
-
isoprenoids
-
mediterranean
- aciduria
- hereditary
-
receptor-associated
- hyperimmunoglobulinemia
-
vinyl
- ketone
-
cryopyrin-associated
- phosphomevalonate
-
febrile
- igd
-
isopentenyl
-
monogenic
-
farnesyl
-
tnfrsf1a
- isoprene
-
hyper-igd
-
anakinra
- rash
- lymphadenopathy
- hmg-coa
- inflammasome
-
geranylgeranylation
- amyloidosis
-
aphthous
- porokeratosis
- arthralgia
-
non-sterol
-
pyoderma
- nod2
- papa
- autoinflammation
- gangrenosum
-
canakinumab
- adenitis
-
pstpip1
-
hyperimmunoglobulin
- medicine
-
hepatosplenomegaly
-
cholesterogenesis
-
etanercept
-
cryopyrin
- synthesis
- diagnostics
Reaction
Synonyms
ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK
ECTree
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Reaction
Reaction on EC 2.7.1.36 - mevalonate kinase
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ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
sequential mechanism
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ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
catalytic reaction mechanism, substrate binding structure involves key residue His25 in a deep cavity lined by highly conserved residues, Lys18, Asp155, Val202, and Thr283 are involved in catalysis
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
role for residue E193 in interacting with the cation of the MgATP substrate, and for D204 as the catalytic base that facilitates deprotonation of the C5 hydroxyl of mevalonic acid
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