2.7.1.36: mevalonate kinase
This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.
Word Map on EC 2.7.1.36
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2.7.1.36
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fever
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autoinflammatory
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cholesterol
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isoprenoids
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mediterranean
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aciduria
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hereditary
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receptor-associated
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hyperimmunoglobulinemia
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vinyl
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ketone
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cryopyrin-associated
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phosphomevalonate
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febrile
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igd
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isopentenyl
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monogenic
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farnesyl
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tnfrsf1a
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isoprene
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hyper-igd
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anakinra
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rash
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lymphadenopathy
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hmg-coa
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inflammasome
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geranylgeranylation
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amyloidosis
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aphthous
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porokeratosis
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arthralgia
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non-sterol
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pyoderma
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nod2
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papa
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autoinflammation
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gangrenosum
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canakinumab
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adenitis
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pstpip1
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hyperimmunoglobulin
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medicine
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hepatosplenomegaly
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cholesterogenesis
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etanercept
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cryopyrin
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synthesis
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diagnostics
- 2.7.1.36
- fever
- autoinflammatory
- cholesterol
-
isoprenoids
-
mediterranean
- aciduria
- hereditary
-
receptor-associated
- hyperimmunoglobulinemia
-
vinyl
- ketone
-
cryopyrin-associated
- phosphomevalonate
-
febrile
- igd
-
isopentenyl
-
monogenic
-
farnesyl
-
tnfrsf1a
- isoprene
-
hyper-igd
-
anakinra
- rash
- lymphadenopathy
- hmg-coa
- inflammasome
-
geranylgeranylation
- amyloidosis
-
aphthous
- porokeratosis
- arthralgia
-
non-sterol
-
pyoderma
- nod2
- papa
- autoinflammation
- gangrenosum
-
canakinumab
- adenitis
-
pstpip1
-
hyperimmunoglobulin
- medicine
-
hepatosplenomegaly
-
cholesterogenesis
-
etanercept
-
cryopyrin
- synthesis
- diagnostics
Reaction
Synonyms
ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK
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2.7.1.36 mevalonate kinaseAdvanced search results
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results (General Information
General Information on EC 2.7.1.36 - mevalonate kinase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
GbAACT and GbMVK are highly homologous to AACT genes and MVK genes from other plant species. The structure of GbMVK monomer contains a ribosomal protein S5 2-type (8-230), a GHMP kinase N-terminal domain (140-220), and a GHMP kinase C-terminal domain (236-390). Ile146-Ala157 is an ATP-binding conserved site. Molecular evolution analysis and phylogenetic analysis, overview
malfunction
metabolism
physiological function
additional information
malfunction
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mutations in the mevalonate kinase gene cause the hyperimmunoglobulin D syndrome, HIDS, an autosomal recessive autoinflammatory disease
malfunction
a mevalonate kinase heterozygous missense mutation C152Y in a patient with disseminated superficial actinic porokeratosis is detected. Disseminated superficial actinic porokeratosis (DSAP) is a genodermatosis with autosomal dominant inheritance and near-complete penetrance clinically featuring uniform 3- to 7-mm annular lesions with scaly borders on sun-exposed face and extremities. The hyperkeratotic rim correlates histopathologically with the presence of a cornoid lamella
metabolism
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the enzyme is part of the mevalonate pathway leading to the production of farnesyl diphosphate and geranylgeranyl diphosphate, overview
metabolism
the enzyme is regulating the mevalonate pathway in Streptococcus pneumoniae, it is strongly feedback-inhibited by diphosphomevalonate, the penultimate compound in the pathway, overview
metabolism
ginkgolides and bilobalides, collectively termed terpene trilactones (TTLs), are terpenoids that form the main active substance of Ginkgo biloba. Terpenoids in the mevalonate (MVA) biosynthetic pathway include acetyl-CoA C-acetyltransferase (AACT) and mevalonate kinase (MVK) as core enzymes, pathways overview. TTL content in Ginkgo biloba can be enhanced by upregulating the transcript levels of some of these genes
metabolism
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mevalonate kinase (MK) is a key enzyme of the mevalonate pathway, which produces the biosynthetic precursors for steroids, including cholesterol, and isoprenoids, the largest class of natural products
metabolism
MVK functions downstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) in the mevalonate pathway. The mevalonate pathway provides crucial molecules to cells, and may be an important metabolic pathway in human skin. Short-chain isoprenoids farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are the intermediate products of the mevalonate pathway, these attach to small G proteins covalently, and serve as molecular switches in many biochemical pathways
metabolism
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the mevalonate pathway is an essential part of isoprenoid biosynthesis leading to production of a diverse class of over 30000 biomolecules including cholesterol, heme, and all steroid hormones. In trypanosomatids, the mevalonate pathway also generates dolichols, which play an essential role in construction of glycosylphosphatidylinositol (GPI) molecules that anchor variable surface proteins (VSGs) to the plasma membrane. Isoprenoid biosynthesis involves one of the most highly regulated enzymes in nature, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), which catalyzes the conversion of HMG-CoA to mevalonic acid. The enzyme mevalonate kinase (MVK) subsequently converts mevalonic acid to 5-phosphomevalonic acid. Presence of mevalonate pathway enzymes in vivo in Trypanosoma evansi during the course of infection
metabolism
the mevalonate pathway is an important metabolic pathway that provides cells with bioactive molecules essential for multiple cellular processes
metabolism
Trypanosoma evansi 29-19
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the mevalonate pathway is an essential part of isoprenoid biosynthesis leading to production of a diverse class of over 30000 biomolecules including cholesterol, heme, and all steroid hormones. In trypanosomatids, the mevalonate pathway also generates dolichols, which play an essential role in construction of glycosylphosphatidylinositol (GPI) molecules that anchor variable surface proteins (VSGs) to the plasma membrane. Isoprenoid biosynthesis involves one of the most highly regulated enzymes in nature, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), which catalyzes the conversion of HMG-CoA to mevalonic acid. The enzyme mevalonate kinase (MVK) subsequently converts mevalonic acid to 5-phosphomevalonic acid. Presence of mevalonate pathway enzymes in vivo in Trypanosoma evansi during the course of infection
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physiological function
thebifunctional enzyme, in addition to playing a classical role in isoprenoid synthesis in lycosomes, it is secreted and modulates host cell signaling required for Trypanosoma cruzi invasion
physiological function
enzyme GbMVK mediates the conversion of mevalonate to mevalonate phosphate and is involved in biosynthesis of ginkgolides and bilobalides, termed terpene trilactones (TTLs), in Ginkgo biloba. GbAACT and GbMVK are functional genes in the cytosolic mevalonate (MVA) biosynthesis pathway
physiological function
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mevalonate kinase (MVK) converts mevalonic acid to 5-phosphomevalonic acid
physiological function
mevalonate kinase (MVK) is an enzyme involved in synthesis of isoprenoids in glycosomes. TcMVK is also secreted into extracellular medium, where it binds HeLa cells and modulates Trypanosoma cruzi cell invasion. Addition of a recombinant form of TcMVK to cultured HeLa cells triggers phosphorylation of MAPK pathway components and proteins involved in actin cytoskeleton changes. Only freshly purified recombinant TcMVK is capable of adding phosphate to mevalonic acid, suggesting that binding to cell host membrane and modulation of Trypanosoma cruzi cell invasion by TcMVK are not due to its catalytic function. TcMVK has two different fnctions
physiological function
MVK catalyzes the phosphorylation of mevalonic acid into 5-phosphomevalonate, and functions downstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) in the mevalonate pathway. The mevalonate pathway provides crucial molecules to cells, and may be an important metabolic pathway in human skin. Analysis of the role of MVK in differentiation, apoptosis and prenylation of keratinocytes, and in the expression of keratin 1 and involucrin, protein prenylation and the processing of small G proteins, overview
physiological function
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thebifunctional enzyme, in addition to playing a classical role in isoprenoid synthesis in lycosomes, it is secreted and modulates host cell signaling required for Trypanosoma cruzi invasion
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physiological function
Trypanosoma evansi 29-19
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mevalonate kinase (MVK) converts mevalonic acid to 5-phosphomevalonic acid
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additional information
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mevalonate kinase and Rho kinase are involved in regulation of BMP-2 mRNA expression, inhibition of both enzymes in osteoblastic MC3T3-E1 cells upregulates BMP-2 mRNA expression
additional information
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structure comparisons of MVKs from different species, active site structure and structure-function analysis, detailed overview
additional information
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TeMVK structure homology modeling, overview. The TeMVK displays a catalytic pocket disposed between the N- and C-terminal domains and formed by the three highly conserved motifs, molecular dynamic simulation demonstrates a stable protein conformation
additional information
Trypanosoma evansi 29-19
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TeMVK structure homology modeling, overview. The TeMVK displays a catalytic pocket disposed between the N- and C-terminal domains and formed by the three highly conserved motifs, molecular dynamic simulation demonstrates a stable protein conformation
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