2.7.1.36: mevalonate kinase
This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.
Word Map on EC 2.7.1.36
-
2.7.1.36
-
fever
-
autoinflammatory
-
cholesterol
-
isoprenoids
-
mediterranean
-
aciduria
-
hereditary
-
receptor-associated
-
hyperimmunoglobulinemia
-
vinyl
-
ketone
-
cryopyrin-associated
-
phosphomevalonate
-
febrile
-
igd
-
isopentenyl
-
monogenic
-
farnesyl
-
tnfrsf1a
-
isoprene
-
hyper-igd
-
anakinra
-
rash
-
lymphadenopathy
-
hmg-coa
-
inflammasome
-
geranylgeranylation
-
amyloidosis
-
aphthous
-
porokeratosis
-
arthralgia
-
non-sterol
-
pyoderma
-
nod2
-
papa
-
autoinflammation
-
gangrenosum
-
canakinumab
-
adenitis
-
pstpip1
-
hyperimmunoglobulin
-
medicine
-
hepatosplenomegaly
-
cholesterogenesis
-
etanercept
-
cryopyrin
-
synthesis
-
diagnostics
- 2.7.1.36
- fever
- autoinflammatory
- cholesterol
-
isoprenoids
-
mediterranean
- aciduria
- hereditary
-
receptor-associated
- hyperimmunoglobulinemia
-
vinyl
- ketone
-
cryopyrin-associated
- phosphomevalonate
-
febrile
- igd
-
isopentenyl
-
monogenic
-
farnesyl
-
tnfrsf1a
- isoprene
-
hyper-igd
-
anakinra
- rash
- lymphadenopathy
- hmg-coa
- inflammasome
-
geranylgeranylation
- amyloidosis
-
aphthous
- porokeratosis
- arthralgia
-
non-sterol
-
pyoderma
- nod2
- papa
- autoinflammation
- gangrenosum
-
canakinumab
- adenitis
-
pstpip1
-
hyperimmunoglobulin
- medicine
-
hepatosplenomegaly
-
cholesterogenesis
-
etanercept
-
cryopyrin
- synthesis
- diagnostics
Reaction
Synonyms
ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK
ECTree
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Metals Ions
Metals Ions on EC 2.7.1.36 - mevalonate kinase
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Ba2+
Ca2+
Co2+
Fe2+
Mg2+
Mn2+
Zn2+
-
in the presence of Mg2+, the enzyme has higher affinity for (R)-mevalonate than ATP
Mg2+
required for full activity, not replaceable by other divalent ions
Mg2+
-
presence of free ATP4- results in a biphasic Lineweaver-Burk plot with 2 apparent Km-values for MgATP2-: 0.14 mM and 0.006 mM
Mg2+
-
Mg2+ becomes increasingly active at higher concentrations and at sufficiently high concentrations the most active metal ion
Mg2+
-
presence of free ATP4- results in a biphasic Lineweaver-Burk plot with 2 apparent Km-values for MgATP2-: 0.14 mM and 0.006 mM
Mn2+
-
higher activation than with Mg2+ at concentrations below approx. 0.008 mM, lower activation than with Mg2+ above
Mn2+
-
can partially replace Mg2+ in activation, maximal activation at 2.5 mM, inhibition above