2.5.1.B41: trifunctional (all-E)-isoprenyl diphospate synthase
This is an abbreviated version!
For detailed information about trifunctional (all-E)-isoprenyl diphospate synthase, go to the full flat file.
Reaction
+ 4 isopentenyl diphosphate = 4 diphosphate +
Synonyms
(all-E)-isoprenyl diphosphate synthase, E-IDS2-L, E-IDS2-S, geranylfarnesyl diphosphate/hexaprenyl diphosphate/heptaprenyl diphosphate synthase, GFPP/HexPP/HepPP synthase, HepS, HepT
ECTree
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General Information
General Information on EC 2.5.1.B41 - trifunctional (all-E)-isoprenyl diphospate synthase
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metabolism
physiological function
hexaprenyl diphosphate and heptaprenyl diphosphate, intermediates of two isoprenoid pathways (acyclic terpenes and menaquinones), are biosynthesized by one trifunctional (all-E)-isoprenyl diphosphate synthase, E-IDS. Geranylfarnesyl diphosphate/hexaprenyl diphosphate and heptaprenyl diphosphate are the primary substrates for the biosynthesis of acyclic terpenes and menaquinone-7, respectively. (All-E)-and E,Z-mixed isoprenyl diphosphates are formed by E-IDSs and Z-IDSs, respectively, which have no sequence similarity with each other
metabolism
Alkalihalobacillus clausii JCM 9138
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hexaprenyl diphosphate and heptaprenyl diphosphate, intermediates of two isoprenoid pathways (acyclic terpenes and menaquinones), are biosynthesized by one trifunctional (all-E)-isoprenyl diphosphate synthase, E-IDS. Geranylfarnesyl diphosphate/hexaprenyl diphosphate and heptaprenyl diphosphate are the primary substrates for the biosynthesis of acyclic terpenes and menaquinone-7, respectively. (All-E)-and E,Z-mixed isoprenyl diphosphates are formed by E-IDSs and Z-IDSs, respectively, which have no sequence similarity with each other
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all-trans-heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), and is used to produce menaquinone-7
physiological function
Alkalihalobacillus clausii JCM 9138
-
all-trans-heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), and is used to produce menaquinone-7
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