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(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate
geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate
geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate
(3)
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate
(3)
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(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate
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geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate
(2)
geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate
(2)
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geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate
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geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
(1)
geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
(1)
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geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
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(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
geranylgeranyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + all-trans-hexaprenyl diphosphate
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.81
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?
additional information
?
-
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.30, low activity
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-
?
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.30
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-
?
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.30, low activity
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-
?
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.30
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-
?
geranylgeranyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + all-trans-hexaprenyl diphosphate
heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.82
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-
?
geranylgeranyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + all-trans-hexaprenyl diphosphate
heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.82
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?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
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?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
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?
additional information
?
-
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formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
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?
additional information
?
-
product identification and determination by mass spectrometry, NMR spectrometry, and TLC
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?
additional information
?
-
product identification and determination by mass spectrometry, NMR spectrometry, and TLC
-
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?
additional information
?
-
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product identification and determination by mass spectrometry, NMR spectrometry, and TLC
-
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?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
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?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
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?
additional information
?
-
product identification and determination by mass spectrometry, NMR spectrometry, and TLC
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?
additional information
?
-
product identification and determination by mass spectrometry, NMR spectrometry, and TLC
-
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
geranylgeranyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + all-trans-hexaprenyl diphosphate
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.81
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-
?
additional information
?
-
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.30, low activity
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-
?
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
4 diphosphate + all-trans-heptaprenyl diphosphate
heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.30, low activity
-
-
?
geranylgeranyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + all-trans-hexaprenyl diphosphate
heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.82
-
-
?
geranylgeranyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + all-trans-hexaprenyl diphosphate
heterodimeric E-IDS (HepS/T), cf. EC 2.5.1.82
-
-
?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
-
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?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
-
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?
additional information
?
-
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formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
-
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?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
-
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?
additional information
?
-
formation of geranylfarnesyl diphosphate and hexaprenyl diphosphate is mediated by heteromeric E-IDS2-S/L. E-IDS2-S or E-IDS2-L alone form no product from dimethylallyl diphosphate, (2E,6E)-farnesyl diphosphate, and geranylgeranyl diphosphate
-
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?
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metabolism
hexaprenyl diphosphate and heptaprenyl diphosphate, intermediates of two isoprenoid pathways (acyclic terpenes and menaquinones), are biosynthesized by one trifunctional (all-E)-isoprenyl diphosphate synthase, E-IDS. Geranylfarnesyl diphosphate/hexaprenyl diphosphate and heptaprenyl diphosphate are the primary substrates for the biosynthesis of acyclic terpenes and menaquinone-7, respectively. (All-E)-and E,Z-mixed isoprenyl diphosphates are formed by E-IDSs and Z-IDSs, respectively, which have no sequence similarity with each other
metabolism
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hexaprenyl diphosphate and heptaprenyl diphosphate, intermediates of two isoprenoid pathways (acyclic terpenes and menaquinones), are biosynthesized by one trifunctional (all-E)-isoprenyl diphosphate synthase, E-IDS. Geranylfarnesyl diphosphate/hexaprenyl diphosphate and heptaprenyl diphosphate are the primary substrates for the biosynthesis of acyclic terpenes and menaquinone-7, respectively. (All-E)-and E,Z-mixed isoprenyl diphosphates are formed by E-IDSs and Z-IDSs, respectively, which have no sequence similarity with each other
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physiological function
all-trans-heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), and is used to produce menaquinone-7
physiological function
-
all-trans-heptaprenyl diphosphate is biosynthesized from isopentenyl diphosphate and farnesyl diphosphate by heterodimeric E-IDS (HepS/T), and is used to produce menaquinone-7
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Ueda, D.; Yamaga, H.; Murakami, M.; Totsuka, Y.; Shinada, T.; Sato, T.
Biosynthesis of sesterterpenes, head-to-tail triterpenes, and sesquarterpenes in Bacillus clausii: identification of multifunctional enzymes and analysis of isoprenoid metabolites
ChemBioChem
16
1371-1377
2015
Alkalihalobacillus clausii (S6AGL5), Alkalihalobacillus clausii (S6B6P7), Alkalihalobacillus clausii, Alkalihalobacillus clausii JCM 9138 (S6AGL5), Alkalihalobacillus clausii JCM 9138 (S6B6P7)
brenda