2.5.1.26: alkylglycerone-phosphate synthase
This is an abbreviated version!
For detailed information about alkylglycerone-phosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.26
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2.5.1.26
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ether
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shikimate
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dah7ps
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chorismate
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plasmalogens
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chondrodysplasia
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rhizomelic
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punctata
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zellweger
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prephenate
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phenylalanine-sensitive
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dhap-at
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4.1.2.15
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tyrosine-sensitive
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8-phosphate
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hexadecanol
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5-enolpyruvylshikimate
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d-erythrose
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tryptophan-sensitive
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plasmalogen-deficient
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medicine
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dihydroxyacetone-phosphate
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pharmacology
- 2.5.1.26
- ether
- shikimate
- dah7ps
- chorismate
- plasmalogens
-
chondrodysplasia
-
rhizomelic
- punctata
- zellweger
- prephenate
-
phenylalanine-sensitive
- dhap-at
-
4.1.2.15
-
tyrosine-sensitive
-
8-phosphate
- hexadecanol
-
5-enolpyruvylshikimate
- d-erythrose
-
tryptophan-sensitive
-
plasmalogen-deficient
- medicine
-
dihydroxyacetone-phosphate
- pharmacology
Reaction
Synonyms
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, ADPS, ADS, AGPS, alkyl DHAP synthetase, alkyl dihydroxyacetone phosphate synthase, alkyl dihydroxyacetone phosphate synthetase, alkyl-DHAP, alkyl-dihydroxyacetonephosphate synthase, alkyl-dihydroxyacetonephosphate-synthase, alkyldihydroxyacetone phosphate synthase, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetonephosphate synthetase, alkylglycerone phosphate synthase, alkylglyceronephosphate synthase, DHAP-S, synthase, alkylglycerone phosphate, synthetase, alkyldihydroxyacetone phosphate
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medicine
pharmacology
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enzyme levels are strongly reduced in fibroblasts derived from Zellweger syndrome and rhizomelic chondrodysplasia punctata patients
medicine
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in fibroblast cell lines derived from Zellweger syndrome and rhizomelic chondrodysplasia punctata patients enzyme is mainly present as precursor form
medicine
enzyme AGPS may be a potential glioma and hepatic carcinoma therapeutic target
alkylglycerone phosphate synthase is an oncogene and can be considered as an antitumor drug target. The study designs novel nitrogenous heterocyclic compound improving targetability by computer-aided drug design technology targeting alkylglycerone phosphate synthase. A total of 12 nitrogenous heterocyclic compounds are designed and predicted the absorption, distribution, metabolism and excretion parameters/toxicity. Their activity in terms of proliferation inhibition, cell cycle arrest and apoptosis induction as then measured using an MTS assay and a high-content screening system in U251 cells. The results show that anti-glioma activity is present in several compounds, which is in accordance with the computer prediction. These compounds may be suitable for the development of a glioma therapeutic drug
pharmacology
the enzyme reduces ether lipid levels in tumor cells and thus decreases cancer pathogenicity. It is considered to be a target of antitumor drugs, with specific inhibitors expected to have marked advantages over traditional chemotherapy methods