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2.3.1.85: fatty-acid synthase system

This is an abbreviated version!
For detailed information about fatty-acid synthase system, go to the full flat file.

Word Map on EC 2.3.1.85

Reaction

acetyl-CoA
+ 7 malonyl-CoA + 14 NADPH + 14 H+ =
hexadecanoate
 + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O

Synonyms

F09E10.3 protein, FAS, FAS-II, FASI, FASII, FASN, fatty acid synthase, fatty acid synthase I, fatty acid synthase II, fatty acid synthase type 2, fatty-acid synthase, type 2 dissociative FAS, type 2 fatty acid synthase, type II fatty acid synthase, yeast fatty acid synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.85 fatty-acid synthase system

Expression

Expression on EC 2.3.1.85 - fatty-acid synthase system

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
(10E,12Z)-octadec-10,12-dienoic acid downregulates FAS expression in a concnetration-dependent manner, while (9Z,11E)-octadec-9,11-dienoic acid has no effect. (10E,12Z)-octadec-10,12-dienoic acid at 0.05 mM decreases FAS expression in MCF-7 cells by 52%, at 0.1 mM (10E,12Z)-octadec-10,12-dienoic acid, FAS protein is downregulated in MCF-7 (80%), LnCaP (27%), and HT-29 (61%) cells
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17beta-estradiol increases FAS expression, estrogen induces FAS expression
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C75 downregulates FASN mRNA in A2780 with an IC50 after 3d of 0.00525 mg/ml and an IT50 (time required for 50% inhibition) at 0.007 mg/ml of 21.5 h. This corresponds with FASN protein downregulation (IC50 = 0.00415 mg/ml), although the dynamics are slower (IT50 = 40 h). Pelitinib, given for 3d, abrogates FASN mRNA and protein in A-2780 cellsat doses as low as 0.003 mM
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expression of Fas1 and Fas2 is significantly elevated by the presence of glucose
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FAS expression is reduced by 25% in Ki-ras-induced actin-interacting protein-deficient liver
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fatty acid synthase is overexpressed in ovarian cancer
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hepatic fatty acid synthase activity is significantly higher after week 1 of refeeding
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isoleucine, whey, leucine, valine, skim milk, and casein downregulate the expression of fatty acid synthase in a concentration-dependent manner, a plateau is reached at 1.0% (w/v) skim milk and casein corresponding to about 40% inhibition of FAS expression, whey leads to 54% inhibition of FAS expression at 2.0%(w/v)
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mithramycin inhibits FAS expression, transfection of transcription factor Sp1 siRNA suppresses FAS expression
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oleic acid and Tween 80 downregulate the expression of the fatty acid synthase while myristic acid, stearic acid, and Tween 40 do not
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relative FASN mRNA expression is upregulated by 9 and 5fold, respectively, for high-concentrate diet (85% concentrate: 15% roughage) and diet on endophyte-free tall fescue pastures with corn grain supplement compared with pasture diet, grain feeding upregulates FASN mRNA expression
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the stromal cell-derived factor-1 alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element binding protein-1 activation in cancer cells. Sterol regulatory element-binding protein-1 is a major modulator of fatty acid synthase transcription. Also recombinant stromal cell-derived factor-1 alpha-induced phosphatidylinositol-3'-kinase/protein kinase B (Akt) phosphorylation is involved in the expression or activities of fatty acid synthase
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transcription factor Sp3 and Sp4 siRNAs do not affect FAS expression
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