2.3.1.260: tetracycline polyketide synthase

This is an abbreviated version!
For detailed information about tetracycline polyketide synthase, go to the full flat file.

Reaction

Synonyms

minimal PKS, octaketide minimal PKS, otc PKS, oxy, OxyA, oxyABC, OxyB, OxyC, oxytetracycline PKS, oxytetracycline polyketide synthase, type II minimal polyketide synthase, type II PKS

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.260 tetracycline polyketide synthase

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Results	in table
5	AA Sequence
1	Cloned(Commentary)
2	General Information
4	Natural Substrates/ Products (Substrates)
6	Organism
5	Pathway
1	Purification (Commentary)
1	Reaction
6	Reference
5	Substrates and Products (Substrate)
21	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.260 - tetracycline polyketide synthase

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SYSTEMATIC NAME

IUBMB Comments

malonyl-CoA:malonamoyl-[OxyC acyl-carrier protein] malonyltransferase

The synthesis, in the bacterium Streptomyces rimosus, of the tetracycline antibiotics core skeleton requires a minimal polyketide synthase (PKS) consisting of a ketosynthase (KS), a chain length factor (CLF), and an acyl-carrier protein (ACP). Initiation involves an amide-containing starter unit that becomes the C-2 amide that is present in the tetracycline compounds. Following the initiation, the PKS catalyses the iterative condensation of 8 malonyl-CoA molecules to yield the polyketide backbone of tetracycline. Throughout the proccess, the nascent chain is attached to the OxyC acyl-carrier protein.