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2.3.1.260: tetracycline polyketide synthase

This is an abbreviated version!
For detailed information about tetracycline polyketide synthase, go to the full flat file.

Word Map on EC 2.3.1.260

Reaction

malonamoyl-[OxyC acyl-carrier protein]
+ 8 malonyl-CoA =
18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein]
+ 8 CO2 + 8 CoA

Synonyms

minimal PKS, octaketide minimal PKS, otc PKS, oxy, OxyA, oxyABC, OxyB, OxyC, oxytetracycline PKS, oxytetracycline polyketide synthase, type II minimal polyketide synthase, type II PKS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.260 tetracycline polyketide synthase

Reference

Reference on EC 2.3.1.260 - tetracycline polyketide synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, W.; Ames, B.D.; Tsai, S.C.; Tang, Y.
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase
Appl. Environ. Microbiol.
72
2573-2580
2006
Streptomyces rimosus, Streptomyces rimosus CH999
Manually annotated by BRENDA team
Yu, L.; Cao, N.; Wang, L.; Xiao, C.; Guo, M.; Chu, J.; Zhuang, Y.; Zhang, S.
Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes
Enzyme Microb. Technol.
50
318-324
2012
Streptomyces rimosus, Streptomyces rimosus M4018
Manually annotated by BRENDA team
Fu, H.; Ebert-Khosla, S.; Hopwood, D.; Khosla, C.
Relaxed specificity of the oxytetracycline polyketide synthase for an acetate primer in the absence of a malonamyl primer
J. Am. Chem. Soc.
116
6443-6444
1994
Streptomyces rimosus
-
Manually annotated by BRENDA team
Zhang, W.; Tang, Y.
In vitro analysis of type II polyketide synthase
Methods Enzymol.
459
367-393
2009
Streptomyces coelicolor
Manually annotated by BRENDA team