2.3.1.260: tetracycline polyketide synthase
This is an abbreviated version!
For detailed information about tetracycline polyketide synthase, go to the full flat file.
Word Map on EC 2.3.1.260
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2.3.1.260
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ketosynthase
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ketoreductase
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actinorhodin
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malonylation
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tetracenomycin
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decaketide
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self-malonylation
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glaucescens
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mcats
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benzoisochromanequinones
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aromatases
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holo-acps
- 2.3.1.260
-
ketosynthase
- ketoreductase
-
actinorhodin
-
malonylation
-
tetracenomycin
-
decaketide
-
self-malonylation
- glaucescens
-
mcats
-
benzoisochromanequinones
- aromatases
-
holo-acps
Reaction
+ 8 malonyl-CoA = + 8 CO2 + 8 CoA
Synonyms
minimal PKS, octaketide minimal PKS, otc PKS, oxy, OxyA, oxyABC, OxyB, OxyC, oxytetracycline PKS, oxytetracycline polyketide synthase, type II minimal polyketide synthase, type II PKS
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Reference
Reference on EC 2.3.1.260 - tetracycline polyketide synthase
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Zhang, W.; Ames, B.D.; Tsai, S.C.; Tang, Y.
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase
Appl. Environ. Microbiol.
72
2573-2580
2006
Streptomyces rimosus, Streptomyces rimosus CH999
Yu, L.; Cao, N.; Wang, L.; Xiao, C.; Guo, M.; Chu, J.; Zhuang, Y.; Zhang, S.
Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes
Enzyme Microb. Technol.
50
318-324
2012
Streptomyces rimosus, Streptomyces rimosus M4018
Fu, H.; Ebert-Khosla, S.; Hopwood, D.; Khosla, C.
Relaxed specificity of the oxytetracycline polyketide synthase for an acetate primer in the absence of a malonamyl primer
J. Am. Chem. Soc.
116
6443-6444
1994
Streptomyces rimosus
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